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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/51369
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dc.creatorAmanda Souto Machadopt_BR
dc.creatorCláudia Regina Vieirapt_BR
dc.creatorUlisses Alves Pereirapt_BR
dc.creatorTheles de Oliveira Costapt_BR
dc.creatorJoão Marcus Oliveira Andradept_BR
dc.creatorRobson a s Dos Santospt_BR
dc.creatorSergio Henrique Sousa Santospt_BR
dc.creatorJanaína Ribeiro Oliveirapt_BR
dc.creatorDeborah Farias Lelispt_BR
dc.creatorVictor Hugo Dantas Guimarãespt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorIgor Viana Brandipt_BR
dc.creatorBruna Mara Aparecida de Carvalho Mesquitapt_BR
dc.creatorDiego Vicente da Costapt_BR
dc.date.accessioned2023-03-30T14:47:22Z-
dc.date.available2023-03-30T14:47:22Z-
dc.date.issued2021-
dc.citation.volume28pt_BR
dc.citation.issue10pt_BR
dc.citation.spage1127pt_BR
dc.citation.epage1137pt_BR
dc.identifier.doihttp://dx.doi.org/10.2174/0929866528666210816115645pt_BR
dc.identifier.issn1875-5305pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/51369-
dc.description.resumoBackground: Obesity is a serious health problem that dysregulate Renin-Angiotensin System (RAS) and intestinal microbiota. Objective: The present study aimed to evaluate the Angiotensin-(1-7) [ANG-(1-7)] oral formulation effects on obese mice intestinal microbiota. Methods: Mice were divided into four groups: obese and non-obese treated with ANG-(1-7) and obese and non-obese without ANG-(1-7) during four weeks. Results: We observed a significant decrease in the fasting plasma glucose, total cholesterol, triglycerides, and Low-density lipoprotein levels and increased High-density lipoprotein in animals treated with ANG-(1-7). The histological analysis showed intestinal villi height reduction in mice treated with ANG-(1-7). Additionally, increased Bacteroidetes and decreased Firmicutes (increased Bacteroidetes/ Firmicutes ratio) and Enterobacter cloacae populations were observed in the High-Fat Diet + ANG-(1-7) group. Receptor toll-like 4 (TLR4) intestinal mRNA expression was reduced in the HFD+ANG-(1-7) group. Finally, the intestinal expression of the neutral amino acid transporter (B0AT1) was increased in animals treated with ANG-(1-7), indicating a possible mechanism associated with tryptophan uptake. Conclusion: The results of the present study suggest for the first time an interaction between oral ANG-(1-7) and intestinal microbiota modulation.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofProtein and peptide letters-
dc.rightsAcesso Restritopt_BR
dc.subject.otherIntestinos -- Microbiologiapt_BR
dc.subject.otherEndotoxinapt_BR
dc.subject.otherMetabolismopt_BR
dc.subject.otherSistema renina-angiotensinapt_BR
dc.subject.otherIntestino delgadopt_BR
dc.titleOral angiotensin-(1-7) peptide modulates intestinal microbiota improving metabolic profile in obese micept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.eurekaselect.com/article/117376ipt_BR
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