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http://hdl.handle.net/1843/51369
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DC Field | Value | Language |
---|---|---|
dc.creator | Amanda Souto Machado | pt_BR |
dc.creator | Cláudia Regina Vieira | pt_BR |
dc.creator | Ulisses Alves Pereira | pt_BR |
dc.creator | Theles de Oliveira Costa | pt_BR |
dc.creator | João Marcus Oliveira Andrade | pt_BR |
dc.creator | Robson a s Dos Santos | pt_BR |
dc.creator | Sergio Henrique Sousa Santos | pt_BR |
dc.creator | Janaína Ribeiro Oliveira | pt_BR |
dc.creator | Deborah Farias Lelis | pt_BR |
dc.creator | Victor Hugo Dantas Guimarães | pt_BR |
dc.creator | Alfredo Maurício Batista de Paula | pt_BR |
dc.creator | André Luiz Sena Guimarães | pt_BR |
dc.creator | Igor Viana Brandi | pt_BR |
dc.creator | Bruna Mara Aparecida de Carvalho Mesquita | pt_BR |
dc.creator | Diego Vicente da Costa | pt_BR |
dc.date.accessioned | 2023-03-30T14:47:22Z | - |
dc.date.available | 2023-03-30T14:47:22Z | - |
dc.date.issued | 2021 | - |
dc.citation.volume | 28 | pt_BR |
dc.citation.issue | 10 | pt_BR |
dc.citation.spage | 1127 | pt_BR |
dc.citation.epage | 1137 | pt_BR |
dc.identifier.doi | http://dx.doi.org/10.2174/0929866528666210816115645 | pt_BR |
dc.identifier.issn | 1875-5305 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/1843/51369 | - |
dc.description.resumo | Background: Obesity is a serious health problem that dysregulate Renin-Angiotensin System (RAS) and intestinal microbiota. Objective: The present study aimed to evaluate the Angiotensin-(1-7) [ANG-(1-7)] oral formulation effects on obese mice intestinal microbiota. Methods: Mice were divided into four groups: obese and non-obese treated with ANG-(1-7) and obese and non-obese without ANG-(1-7) during four weeks. Results: We observed a significant decrease in the fasting plasma glucose, total cholesterol, triglycerides, and Low-density lipoprotein levels and increased High-density lipoprotein in animals treated with ANG-(1-7). The histological analysis showed intestinal villi height reduction in mice treated with ANG-(1-7). Additionally, increased Bacteroidetes and decreased Firmicutes (increased Bacteroidetes/ Firmicutes ratio) and Enterobacter cloacae populations were observed in the High-Fat Diet + ANG-(1-7) group. Receptor toll-like 4 (TLR4) intestinal mRNA expression was reduced in the HFD+ANG-(1-7) group. Finally, the intestinal expression of the neutral amino acid transporter (B0AT1) was increased in animals treated with ANG-(1-7), indicating a possible mechanism associated with tryptophan uptake. Conclusion: The results of the present study suggest for the first time an interaction between oral ANG-(1-7) and intestinal microbiota modulation. | pt_BR |
dc.language | eng | pt_BR |
dc.publisher | Universidade Federal de Minas Gerais | pt_BR |
dc.publisher.country | Brasil | pt_BR |
dc.publisher.department | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS | pt_BR |
dc.publisher.initials | UFMG | pt_BR |
dc.relation.ispartof | Protein and peptide letters | - |
dc.rights | Acesso Restrito | pt_BR |
dc.subject.other | Intestinos -- Microbiologia | pt_BR |
dc.subject.other | Endotoxina | pt_BR |
dc.subject.other | Metabolismo | pt_BR |
dc.subject.other | Sistema renina-angiotensina | pt_BR |
dc.subject.other | Intestino delgado | pt_BR |
dc.title | Oral angiotensin-(1-7) peptide modulates intestinal microbiota improving metabolic profile in obese mice | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.url.externa | https://www.eurekaselect.com/article/117376i | pt_BR |
Appears in Collections: | Artigo de Periódico |
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