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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/51432
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dc.creatorAna Claudia Pelissari Kravchychynpt_BR
dc.creatorRaquel Munhoz da Silveira Campospt_BR
dc.creatorFlávia Campos Corgosinhopt_BR
dc.creatorDeborah Cristina Landi Masquiopt_BR
dc.creatorSofia Emanuelle de Castro Ferreira Vicentept_BR
dc.creatorRaquel munhoz da silveira Campospt_BR
dc.creatorFlávia campos Corgosinhopt_BR
dc.creatorDeborah cristina landi Masquiopt_BR
dc.creatorSofia Emanuelle de Castro Ferreira Vicentept_BR
dc.creatorYasmin Alaby Martins Ferreirapt_BR
dc.creatorPatrícia Leão da Silva Agostinhopt_BR
dc.creatorAline de Piano Ganenpt_BR
dc.creatorLila Missae Oyamapt_BR
dc.creatorLian Tockpt_BR
dc.creatorMarco Túlio de Mellopt_BR
dc.creatorSérgio Tufikpt_BR
dc.creatorAna Raimunda Dâmasopt_BR
dc.date.accessioned2023-03-31T14:29:29Z-
dc.date.available2023-03-31T14:29:29Z-
dc.date.issued2018-
dc.citation.volume72pt_BR
dc.citation.issue4pt_BR
dc.citation.spage279pt_BR
dc.citation.epage286pt_BR
dc.identifier.doihttps://doi.org/10.1159/issn.0250-6807pt_BR
dc.identifier.issn1421-9697pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/51432-
dc.description.resumoBackground: Deregulation of orexigenic and anorexigenic pathways occurs among adolescents with obesity. Alpha-melanocyte-stimulating hormone (α-MSH) is a key catabolic mediator of energy homeostasis and an important anorexigenic neuropeptide in the control of energy balance and thermogenesis. However, it was not well explored if α-MSH can modulate long-term weight loss therapy responses in a dependent manner according to its concentration. Our hypothesis is that a high α-MSH concentration at baseline promotes better modulation of anorexigenic/orexigenic pathways in obese adolescents. Methods: One hundred ten post-pubertal obese adolescents (body mass index >95th percentile) were submitted to 1 year of interdisciplinary therapy (clinical, nutritional, psychological, physical exercise, and physiotherapy support). Body composition and plasma levels of α-MSH, neuropeptide Y (NPY), melanin-concentrating hormone, and agouti-related peptide (AgRP) were measured before and after therapy. The volunteers were grouped on the basis of Tertiles of α-MSH concentration: Low (<0.75 ng/mL), Medium (≤0.76 to ≥1.57 ng/mL), and High (>1.57 ng/mL). Significance was set as p < 0.05. Results: The treatment promoted a significant improvement in body adiposity and fat free mass for all groups. It is important to note that only in the high α-MSH group, a significant increase of the α-MSH/NPY ratio and decrease NPY/AgRP ratio post treatment were observed. Conclusion: The high α-MSH concentration promotes better modulation of anorexigenic/orexigenic pathways in obese adolescents following long-term weight loss therapy and this is important in clinical practice.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEEF - DEPARTAMENTO DE ESPORTESpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAnnals of Nutrition and Metabolismpt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectEnergy balancept_BR
dc.subjectObesitypt_BR
dc.subjectAdolescentspt_BR
dc.subject.otherMetabolismo energéticopt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherAdolescentespt_BR
dc.titleThe long-term impact of high levels of alpha-melanocyte-stimulating hormone in energy balance among obese adolescentspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.karger.com/Journal/Details/223977pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2919-2806pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6132-4349pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8684-7290pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0187-6402pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6913-7879pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6913-7879pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5705-6767pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4025-6257pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6433-0816pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7078-6526pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0834-904Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3896-2208pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4012-4951pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7675-7470pt_BR
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