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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/51493
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dc.creatorDiêgo dos Santos Ferreirapt_BR
dc.creatorPeter Caravanpt_BR
dc.creatorLucas Antônio Miranda Ferreirapt_BR
dc.creatorRicardo José Alvespt_BR
dc.creatorMônica Cristina de Oliveirapt_BR
dc.creatorSamilla Dornellas Fariapt_BR
dc.creatorSávia Caldeira de Araújo Lopespt_BR
dc.creatorCláudia Salviano Teixeirapt_BR
dc.creatorÂngelo Malachias de Souzapt_BR
dc.creatorRogério Magalhães Paniagopt_BR
dc.creatorJosé Dias de Souza Filhopt_BR
dc.creatorBruno Luís de Jesus Pinto Oliveirapt_BR
dc.creatorAlexander Sávio Ramos Guimarãespt_BR
dc.date.accessioned2023-04-03T16:42:53Z-
dc.date.available2023-04-03T16:42:53Z-
dc.date.issued2016-
dc.citation.volume11pt_BR
dc.citation.spage3737pt_BR
dc.citation.epage3751pt_BR
dc.identifier.doihttps://doi.org/10.2147/IJN.S109966pt_BR
dc.identifier.issn1178-2013pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/51493-
dc.description.resumoDespite recent advances in cancer therapy, the treatment of bone tumors remains a major challenge. A possible underlying hypothesis, limitation, and unmet need may be the inability of therapeutics to penetrate into dense bone mineral, which can lead to poor efficacy and high toxicity, due to drug uptake in healthy organs. The development of nanostructured formulations with high affinity for bone could be an interesting approach to overcome these challenges.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE FÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Journal of Nanomedicine-
dc.rightsAcesso Abertopt_BR
dc.subjectHydroxyapatite-targeted formulationspt_BR
dc.subjectBisphosphonatespt_BR
dc.subjectPH-responsive nanostructurespt_BR
dc.subjectBone-tumor treatmentpt_BR
dc.subject.otherCâncerpt_BR
dc.subject.otherLipossomospt_BR
dc.subject.otherOssospt_BR
dc.titleDevelopment of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity and biodistribution evaluation in a mice model of bone metastasispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://pubmed.ncbi.nlm.nih.gov/27563241/pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1505-7950pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3179-6537pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2474-5536pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8703-4283pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5203-0944pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3656-4882pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7687-4746pt_BR
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