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http://hdl.handle.net/1843/51519
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DC Field | Value | Language |
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dc.creator | Bruna Machado Savassi | pt_BR |
dc.creator | Bárbara Fernandes Cordeiro | pt_BR |
dc.creator | Sara Heloisa da Silva | pt_BR |
dc.creator | Emiliano Rosa Oliveira | pt_BR |
dc.creator | Giovanna Belo | pt_BR |
dc.creator | Alessandra Gomes Figueiroa | pt_BR |
dc.creator | Maria Izabel Alves Queiroz | pt_BR |
dc.creator | Ana Maria Caetano Faria | pt_BR |
dc.creator | Juliana Alves | pt_BR |
dc.creator | Tales Fernando da Silva | pt_BR |
dc.creator | Gabriela Munis Campos | pt_BR |
dc.creator | Erick Almeida Esmerino | pt_BR |
dc.creator | Ramon da Silva Rocha | pt_BR |
dc.creator | Mônica Queiroz de Freitas | pt_BR |
dc.creator | Marcia Cristina Silva | pt_BR |
dc.creator | Adriano Gomes da Cruz | pt_BR |
dc.creator | Kátia Duarte Vital | pt_BR |
dc.creator | Simone Odília Antunes Fernandes | pt_BR |
dc.creator | Valbert Nascimento Cardoso | pt_BR |
dc.creator | Leonardo Borges Arcucio | pt_BR |
dc.creator | Gwénaël Jan | pt_BR |
dc.creator | Yves Le Loir | pt_BR |
dc.creator | Alfonso Gala-Garcia | pt_BR |
dc.creator | Fillipe Luiz Rosa do Carmo | pt_BR |
dc.creator | Vasco Azevedo | pt_BR |
dc.date.accessioned | 2023-04-03T20:54:57Z | - |
dc.date.available | 2023-04-03T20:54:57Z | - |
dc.date.issued | 2021-12-10 | - |
dc.citation.volume | 12 | pt_BR |
dc.citation.spage | 1 | pt_BR |
dc.citation.epage | 12 | pt_BR |
dc.identifier.doi | 10.3389/fphar.2021.755871 | pt_BR |
dc.identifier.issn | 16639812 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/1843/51519 | - |
dc.description.resumo | Mucositis is an adverse effect of cancer chemotherapies using 5-Fluorouracil (5-FU). It is characterized by mucosal inflammation, pain, diarrhea, and weight loss. Some studies reported promising healing effects of probiotic strains, when associated with prebiotics, as adjuvant treatment of mucositis. We developed a lyophilized symbiotic product, containing skimmed milk, supplemented with whey protein isolate (WPI) and with fructooligosaccharides (FOS), and fermented by Lactobacillus casei BL23, Lactiplantibacillus plantarum B7, and Lacticaseibacillus rhamnosus B1. In a mice 5-FU mucositis model, this symbiotic lyophilized formulation was able to reduce weight loss and intestinal permeability. This last was determined in vivo by quantifying blood radioactivity after oral administration of 99mTc-DTPA. Finally, histological damages caused by 5-FU-induced mucositis were monitored. Consumption of the symbiotic formulation caused a reduced score of inflammation in the duodenum, ileum, and colon. In addition, it decreased levels of pro-inflammatory cytokines IL-1β, IL-6, IL-17, and TNF-α in the mice ileum. The symbiotic product developed in this work thus represents a promising adjuvant treatment of mucositis. | pt_BR |
dc.description.sponsorship | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico | pt_BR |
dc.description.sponsorship | FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais | pt_BR |
dc.description.sponsorship | CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior | pt_BR |
dc.format.mimetype | pt_BR | |
dc.language | eng | pt_BR |
dc.publisher | Universidade Federal de Minas Gerais | pt_BR |
dc.publisher.country | Brasil | pt_BR |
dc.publisher.department | FAR - DEPARTAMENTO DE ALIMENTOS | pt_BR |
dc.publisher.department | FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS | pt_BR |
dc.publisher.department | ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA | pt_BR |
dc.publisher.initials | UFMG | pt_BR |
dc.relation.ispartof | Frontiers in Pharmacology | - |
dc.rights | Acesso Aberto | pt_BR |
dc.subject | Probiotic | pt_BR |
dc.subject | Chemotherapy | pt_BR |
dc.subject | Prebiotic | pt_BR |
dc.subject | Immunomodulant effects | pt_BR |
dc.subject | Symbiotic | pt_BR |
dc.subject.other | Mucosite | pt_BR |
dc.subject.other | 5-Fluorouracil | pt_BR |
dc.subject.other | Probiótico | pt_BR |
dc.subject.other | Prebiótico | pt_BR |
dc.title | Lyophilized symbiotic mitigates mucositis induced by 5-fluorouracil | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.url.externa | https://www.frontiersin.org/articles/10.3389/fphar.2021.755871/full | pt_BR |
Appears in Collections: | Artigo de Periódico |
Files in This Item:
File | Description | Size | Format | |
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Lyophilized Symbiotic Mitigates Mucositis Induced by 5-Fluorouracil.pdf | 3.59 MB | Adobe PDF | View/Open |
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