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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/51519
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dc.creatorBruna Machado Savassipt_BR
dc.creatorBárbara Fernandes Cordeiropt_BR
dc.creatorSara Heloisa da Silvapt_BR
dc.creatorEmiliano Rosa Oliveirapt_BR
dc.creatorGiovanna Belopt_BR
dc.creatorAlessandra Gomes Figueiroapt_BR
dc.creatorMaria Izabel Alves Queirozpt_BR
dc.creatorAna Maria Caetano Fariapt_BR
dc.creatorJuliana Alvespt_BR
dc.creatorTales Fernando da Silvapt_BR
dc.creatorGabriela Munis Campospt_BR
dc.creatorErick Almeida Esmerinopt_BR
dc.creatorRamon da Silva Rochapt_BR
dc.creatorMônica Queiroz de Freitaspt_BR
dc.creatorMarcia Cristina Silvapt_BR
dc.creatorAdriano Gomes da Cruzpt_BR
dc.creatorKátia Duarte Vitalpt_BR
dc.creatorSimone Odília Antunes Fernandespt_BR
dc.creatorValbert Nascimento Cardosopt_BR
dc.creatorLeonardo Borges Arcuciopt_BR
dc.creatorGwénaël Janpt_BR
dc.creatorYves Le Loirpt_BR
dc.creatorAlfonso Gala-Garciapt_BR
dc.creatorFillipe Luiz Rosa do Carmopt_BR
dc.creatorVasco Azevedopt_BR
dc.date.accessioned2023-04-03T20:54:57Z-
dc.date.available2023-04-03T20:54:57Z-
dc.date.issued2021-12-10-
dc.citation.volume12pt_BR
dc.citation.spage1pt_BR
dc.citation.epage12pt_BR
dc.identifier.doi10.3389/fphar.2021.755871pt_BR
dc.identifier.issn16639812pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/51519-
dc.description.resumoMucositis is an adverse effect of cancer chemotherapies using 5-Fluorouracil (5-FU). It is characterized by mucosal inflammation, pain, diarrhea, and weight loss. Some studies reported promising healing effects of probiotic strains, when associated with prebiotics, as adjuvant treatment of mucositis. We developed a lyophilized symbiotic product, containing skimmed milk, supplemented with whey protein isolate (WPI) and with fructooligosaccharides (FOS), and fermented by Lactobacillus casei BL23, Lactiplantibacillus plantarum B7, and Lacticaseibacillus rhamnosus B1. In a mice 5-FU mucositis model, this symbiotic lyophilized formulation was able to reduce weight loss and intestinal permeability. This last was determined in vivo by quantifying blood radioactivity after oral administration of 99mTc-DTPA. Finally, histological damages caused by 5-FU-induced mucositis were monitored. Consumption of the symbiotic formulation caused a reduced score of inflammation in the duodenum, ileum, and colon. In addition, it decreased levels of pro-inflammatory cytokines IL-1β, IL-6, IL-17, and TNF-α in the mice ileum. The symbiotic product developed in this work thus represents a promising adjuvant treatment of mucositis.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ALIMENTOSpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofFrontiers in Pharmacology-
dc.rightsAcesso Abertopt_BR
dc.subjectProbioticpt_BR
dc.subjectChemotherapypt_BR
dc.subjectPrebioticpt_BR
dc.subjectImmunomodulant effectspt_BR
dc.subjectSymbioticpt_BR
dc.subject.otherMucositept_BR
dc.subject.other5-Fluorouracilpt_BR
dc.subject.otherProbióticopt_BR
dc.subject.otherPrebióticopt_BR
dc.titleLyophilized symbiotic mitigates mucositis induced by 5-fluorouracilpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.frontiersin.org/articles/10.3389/fphar.2021.755871/fullpt_BR
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