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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/51540
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dc.creatorCaroline Mari Ramos Odapt_BR
dc.creatorAntonio Augusto Malfatti Gasperinipt_BR
dc.creatorÂngelo Malachias de Souzapt_BR
dc.creatorGwenaelle Elza Nathalie Pound-Lanapt_BR
dc.creatorVanessa Carla Furtado Mosqueirapt_BR
dc.creatorRenata Salgado Fernandespt_BR
dc.creatorMônica Cristina de Oliveirapt_BR
dc.creatorAndré Luís Branco de Barrospt_BR
dc.creatorElaine Amaral Leitept_BR
dc.date.accessioned2023-04-04T13:34:23Z-
dc.date.available2023-04-04T13:34:23Z-
dc.date.issued2020-
dc.citation.volume188pt_BR
dc.citation.spage1pt_BR
dc.citation.epage8pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.colsurfb.2019.110760pt_BR
dc.identifier.issn1873-4367pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/51540-
dc.description.resumoSimple size observations of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)-2000] (DSPE-mPEG2000) polymeric micelles (PM) with different compositions including or not paclitaxel (PTX) are unable to evidence changes on the nanocarrier structure. In such system a detailed characterization using highly sensitive techniques such as X-ray scattering and asymmetric flow field flow fractionation coupled to multi-angle laser light scattering and dynamic light scattering (AF4-MALS-DLS) is mandatory to observe effects that take place by the addition of PTX and/or more lipid-polymer at PM, leading to complex changes on the structure of micelles, as well as in their supramolecular organization. SAXS and AF4-MALS-DLS suggested that PM can be found in the medium separately and highly organized, forming clusters of PM in the latter case. SAXS fitted parameters showed that adding the drug does not change the average PM size since the increase in core radius is compensated by the decrease in shell radius. SAXS observations indicate that PEG conformation takes place, changing from brush to mushroom depending on the PM composition. These findings directly reflect in in vivo studies of blood clearance that showed a longer circulation time of blank PM when compared to PM containing PTX.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE FÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofColloids and Surfaces B: Biointerfaces-
dc.rightsAcesso Restritopt_BR
dc.subjectPolymeric micellespt_BR
dc.subjectPaclitaxelpt_BR
dc.subjectCancerpt_BR
dc.subject.otherCâncerpt_BR
dc.titlePhysical and biological effects of paclitaxel encapsulation on disteraroylphosphatidylethanolamine-polyethyleneglycol polymeric micellespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S092777651930904Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7449-5400pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8703-4283pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0569-0242pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0368-6090pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7641-6585pt_BR
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