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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/52496
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dc.creatorVictor Hugo Dantas Guimarãespt_BR
dc.creatorJéssica Nayara Basilio Silvapt_BR
dc.creatorDaniela Fernanda de Freitaspt_BR
dc.creatorOtávio Cardoso Filhopt_BR
dc.creatorLuiz Henrique da Silveirapt_BR
dc.creatorBarbhara Mota Marinhopt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorGeraldo Aclécio Melopt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.date.accessioned2023-04-26T12:16:36Z-
dc.date.available2023-04-26T12:16:36Z-
dc.date.issued2021-01-28-
dc.citation.volume28pt_BR
dc.citation.issue7pt_BR
dc.citation.spage769pt_BR
dc.citation.epage780pt_BR
dc.identifier.doi10.2174/0929866528999210128205817pt_BR
dc.identifier.issn1875-5305pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/52496-
dc.description.resumoBackground: Solanum lycocarpum is a medicinal plant used in Brazil with hypoglycemic activity by its fruits use. However, the fruits production is restricted in some periods of the year, differently of leaves. Objective: to evaluate the effects of hydroalcoholic extracts of S. lycocarpum leaves in alloxan-induced diabetic mice. Methods: hydroalcoholic extract of S. lycocarpum was characterized by phytochemical and GCMS analysis. The Antidiabetic activity was assessed following treatment for 22 days with S. lycocarpum extract at 125, 250, and 500 mg/kg. Bodyweight, water, and food intake, glycemia, biochemical parameters, anatomy-histopathology of the pancreas, liver and kidney, and expression of target genes were analyzed. In addition, oral acute toxicity was evaluated. Results: animals treated showed a significant reduction (p < 0.05) in glycemia following a dose of 125 mg/kg. Food intake remained similar for all groups. Decreased polydipsia symptoms were observed after treatment with 250 (p < 0.001) and 500 mg/kg (p < 0.01) compared with diabetic control, although normal rates were observed when 125 mg/kg was administered. A protective effect was also observed in the pancreas, liver, and kidneys, through the regeneration of the islets. Hypoglycemic activity can be attributed to myo-inositol, which stimulates insulin secretion, associated with α-tocopherol, which prevents damage from oxidative stress and apoptosis of β-pancreatic cells by an increased Catalase (CAT) and Glutathione peroxidase 4 (GPX4) mRNA expression. The toxicological test demonstrated safe oral use of the extract under the present conditions. Conclusion: hydroalcoholic extract of S. lycocarpum promotes the regulation of diabetes in the case of moderate glycemic levels, by decreasing glycemia and exerting protective effects on the islets.pt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofProtein & Peptide Letters-
dc.rightsAcesso Restritopt_BR
dc.subject.otherDiabetespt_BR
dc.subject.otherPlantas medicinaispt_BR
dc.subject.otherMedicina popularpt_BR
dc.subject.otherAloxanapt_BR
dc.subject.otherQuímica vegetalpt_BR
dc.titleHydroalcoholic extract of Solanum lycocarpum A. St. Hil. (Solanaceae) leaves improves alloxan-induced diabetes complications in micept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.eurekaselect.com/article/113765pt_BR
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