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dc.creatorAudrey Handyara Bicalhopt_BR
dc.creatorFabio Ribeiro dos Santospt_BR
dc.creatorDaniele Cristina Moreirapt_BR
dc.creatorLuís Paulo Oliveirapt_BR
dc.creatorAmanda Souto Machadopt_BR
dc.creatorLucyana Conceição Fariaspt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorSergio Henrique Sousa Santospt_BR
dc.description.resumoBackground: malnutrition induced by dietary restriction produces several metabolic changes that affect body weight, the digestive system, and annex organs, including the liver. Malnutrition generates an inflammatory state and increases oxidative stress. The liver is one of the body vital organs, becoming necessary to analyze the impact of food supplementation on the repair of possible changes that may occur in this organ due to malnutrition. Aims: to evaluate the effects of a low-cost supplementation derived from Buriti and dairy byproducts on liver recovery in malnourished mice, focusing on the expression of oxidative stressrelated genes, as well as biochemical and histological parameters. Methods: swiss mice were divided into six groups and submitted to two treatment phases: food restriction, for malnutrition onset; and renutrition, with mice being fed with different diets. Results: our results indicate that dietary supplementation was successful in recovering liver damage caused by malnutrition in animal models. The new supplement has been shown to recover liver damage with similar or superior results compared to the commercial reference supplement on the market. Conclusion: our work presents a new composition of low cost food supplement based on buriti and dairy by-products, proven to be effective in the malnutrition treatment of malnutrition. The improvements were proven through the recovery of body weight, reduction of inflammation and oxidative stress.pt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.relation.ispartofRecent Patents on Food, Nutrition & Agriculture-
dc.rightsAcesso Restritopt_BR
dc.subject.otherSuplementos dietéticospt_BR
dc.subject.otherFígado - Doençaspt_BR
dc.subject.otherEstresse oxidativopt_BR
dc.titleLiver damage produced by malnutrition is improved by dietary supplementation in mice: assessment of a supplement based on buriti (a cerrado fruit) and dairy by-productspt_BR
dc.typeArtigo de Periódicopt_BR
Appears in Collections:Artigo de Periódico

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