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Type: Artigo de Periódico
Title: Liver damage produced by malnutrition is improved by dietary supplementation in mice: assessment of a supplement based on buriti (a cerrado fruit) and dairy by-products
Authors: Audrey Handyara Bicalho
Fabio Ribeiro dos Santos
Daniele Cristina Moreira
Luís Paulo Oliveira
Amanda Souto Machado
Lucyana Conceição Farias
Alfredo Maurício Batista de Paula
André Luiz Sena Guimarães
Sergio Henrique Sousa Santos
Abstract: Background: malnutrition induced by dietary restriction produces several metabolic changes that affect body weight, the digestive system, and annex organs, including the liver. Malnutrition generates an inflammatory state and increases oxidative stress. The liver is one of the body vital organs, becoming necessary to analyze the impact of food supplementation on the repair of possible changes that may occur in this organ due to malnutrition. Aims: to evaluate the effects of a low-cost supplementation derived from Buriti and dairy byproducts on liver recovery in malnourished mice, focusing on the expression of oxidative stressrelated genes, as well as biochemical and histological parameters. Methods: swiss mice were divided into six groups and submitted to two treatment phases: food restriction, for malnutrition onset; and renutrition, with mice being fed with different diets. Results: our results indicate that dietary supplementation was successful in recovering liver damage caused by malnutrition in animal models. The new supplement has been shown to recover liver damage with similar or superior results compared to the commercial reference supplement on the market. Conclusion: our work presents a new composition of low cost food supplement based on buriti and dairy by-products, proven to be effective in the malnutrition treatment of malnutrition. The improvements were proven through the recovery of body weight, reduction of inflammation and oxidative stress.
Subject: Desnutrição
Suplementos dietéticos
Fígado - Doenças
Estresse oxidativo
language: eng Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
Rights: Acesso Restrito
metadata.dc.identifier.doi: 10.2174/2212798411999210101224626
Issue Date: 1-Jan-2021
metadata.dc.relation.ispartof: Recent Patents on Food, Nutrition & Agriculture
Appears in Collections:Artigo de Periódico

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