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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/52609
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dc.creatorRicardo Reis Oliveirapt_BR
dc.creatorWarley Luciano Fonseca Tavarespt_BR
dc.creatorAndressa Lamari da Silva Pereira Reispt_BR
dc.creatorV. A. Silvapt_BR
dc.creatorLeda Quercia Vieirapt_BR
dc.creatorAntônio Paulino Ribeiro Sobrinhopt_BR
dc.date.accessioned2023-04-27T19:37:47Z-
dc.date.available2023-04-27T19:37:47Z-
dc.date.issued2018-
dc.citation.volume51pt_BR
dc.citation.issue11pt_BR
dc.citation.spage1253pt_BR
dc.citation.epage1260pt_BR
dc.identifier.doihttps://doi.org/10.1111/iej.12944pt_BR
dc.identifier.issn13652591pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/52609-
dc.description.resumoAim: To evaluate the expression of TNF-α, IL-6, IFN-γ, TGF-β, IL-4, IL-10, RANKL, RANK and OPG on mouse calvarial bone treated with MTA, Geristore® and Emdogain® . Methodology: Bone wounds were made on the heads of C57BL/6 mice, breaking the periosteum and the cortical surface of the calvaria. Each repair agent was inserted into sectioned Eppendorf microtubes and placed on the bone wound, and soft tissues were sutured. At 14 and 21 days, animals were sacrificed and the treated region was dissected. The calvaria bone was removed, and RNA was extracted. mRNA expression of the aforementioned cytokines was assessed using real-time PCR. Data were analysed by nonparametric methods, including the Mann-Whitney and Kruskal-Wallis tests (P < 0.05). Results: Following treatment with Emdogain® and MTA, mRNA expression of RANKL, RANK and OPG increased significantly (P < 0.05) between days 14 to 21. Geristore® did not alter the basal expression of these mediators during the same period of evaluation. Whilst treatment with Emdogain® did cause a significant increase in TNF-α mRNA expression between days 14 and 21 (P < 0.05), treatment with MTA did not alter the basal expression of this cytokine at either experimental time point. However, TNF-α mRNA expression was down-regulated significantly at day 21 (P < 0.05) when Geristore® was applied. A significant increase in the mRNA expression of IL-6, TGF-β, IL-10, IL-4 and IFN-γ was observed with Emdogain® and MTA treatment between days 14 to 21, whereas Geristore® reduced significantly the expression of IL-6, TGF-β and IL-4 (P < 0.05). Conclusion: The clinical indication of these repair agents depends on the root resorption diagnosis. Whilst MTA and Emdogain® induce a pro- and anti-inflammatory response early and late, respectively, Geristore® was not associated with an inflammatory reaction when compared with both repair agents.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Endodontic Journalpt_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherCytokinespt_BR
dc.subject.otherRNApt_BR
dc.subject.otherWounds and injuriespt_BR
dc.subject.otherBone and bonespt_BR
dc.titleCytokine expression in response to root repair agentspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/iej.12944pt_BR
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