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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/52686
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dc.creatorWarne Pedro de Andradept_BR
dc.creatorLetícia da Conceição Bragapt_BR
dc.creatorLuciana Maria Silvapt_BR
dc.creatorAgnaldo Lopes da Silva Filhopt_BR
dc.creatorNikole Gontijo Gonçalvespt_BR
dc.date.accessioned2023-04-28T20:38:39Z-
dc.date.available2023-04-28T20:38:39Z-
dc.date.issued2019-11-14-
dc.citation.volume19pt_BR
dc.citation.issue1pt_BR
dc.citation.spage359pt_BR
dc.citation.epage367pt_BR
dc.identifier.doihttps://doi.org/10.3892/ol.2019.11095pt_BR
dc.identifier.issn1792-1082pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/52686-
dc.description.resumoAbstract. Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, with the presence of chemoresistance contributing to the poor prognosis. Heat Shock Proteins (HSPs) genes are activated in response to pathophysiological stress and serve a role in a variety of stages in carcinogenesis, acting primarily as anti‑apoptotic agents and in chemotherapy resistance in a variety of tumor types. The current study evaluated the HSP gene expression profile in women with ovarian cancer (OC) and their correlation with clinical and pathological aspects of patients with OC. A total of 51 patients included in the current study were divided into four groups: Primary Epithelial Ovarian Cancer (EOC; n=14), metastatic EOC (n=11), ovarian serous cystadenoma (n=7) and no evidence of ovarian malignancy or control groups (n=19). RNA extraction and reverse transcription‑quantitative (RT‑q) PCR was then performed on the samples obtained. RT‑qPCR was performed to compare TNF receptor associated protein 1 (TRAP1), heat shock protein family (HSP) HSPB1, HSPD1, HSPA1A and HSPA1L expression in primary and metastatic EOCs. TRAP1, HSPB1, HSPD1, HSPA1A and HSPA1L gene expression did not differ among groups. HSPA1A, HSPA1L and TRAP1 were revealed to be underexpressed in the primary and metastatic EOC groups, with HSPA1L exhibiting the lowest expression. TRAP1 expression was higher in tumors at stages I/II compared with those at stages III/IV. No correlation was exhibited between HSP expression and age, menarche, menopause, parity, period after menopause initiation, cytoreduction, CA‑125 or overall and disease‑free survival. HSPA1A was negatively correlated with the risk of mortality from OC. The results indicated that the downregulation of HSPA1A, HSPA1L and TRAP1 could be associated with the clinical prognostic features of women with EOC.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofOncology Letters-
dc.rightsAcesso Abertopt_BR
dc.subjectOvarian cancerpt_BR
dc.subjectPrognosispt_BR
dc.subjectResistance to chemotherapypt_BR
dc.subjectHeat shock proteinspt_BR
dc.subjectGene expressionpt_BR
dc.subject.otherNeoplasias ovarianaspt_BR
dc.subject.otherPrognósticopt_BR
dc.subject.otherTratamento farmacológicopt_BR
dc.subject.otherProteínas de choque térmicopt_BR
dc.subject.otherExpressão gênicapt_BR
dc.titleHSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancerpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.spandidos-publications.com/10.3892/ol.2019.11095#pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8486-7861pt_BR
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