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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/52788
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dc.creatorKeila Lopes Mendespt_BR
dc.creatorDeborah de Farias Lelispt_BR
dc.creatorDaniela Fernanda de Freitaspt_BR
dc.creatorLuiz Henrique da Silveirapt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorJanaína Ribeiro de Oliveirapt_BR
dc.creatorMariléia Chaves Andradept_BR
dc.creatorSérgio Avelino Mota Nobrept_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.date.accessioned2023-05-04T11:12:12Z-
dc.date.available2023-05-04T11:12:12Z-
dc.date.issued2021-02-14-
dc.citation.volume48pt_BR
dc.citation.spage1725pt_BR
dc.citation.epage1734pt_BR
dc.identifier.doihttps://doi.org/10.1007/s11033-021-06190-7pt_BR
dc.identifier.issn1573-4978pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/52788-
dc.description.resumoThe present study aimed to evaluate the effects of resveratrol, a nutraceutical polyphenol, and Lactococcus lactis (bacteria probiotic), on metabolic parameters and hepatic proinflammatory markers expression. C57BL/6 mice were divided into 4 groups: Standard (ST), Lactococcus lactis (LL), Resveratrol (RSV), and Lactococcus lactis plus resveratrol (LL + RSV). Lactococcus lactis and resveratrol were administered by orogastric gavage. Blood parameters were assessed (total cholesterol, triglycerides, ALT and AST). IL-6 mRNA expression was evaluated by Real-time PCR and TNF-α protein expression was assessed by immunohistochemistry. The main findings showed that resveratrol and Lactococcus lactis association decreased body weight, aspartate aminotransferase and total cholesterol levels. LL and LL + RSV decreased triglycerides levels and IL-6 and TNF-α expression. These results open a perspective of using resveratrol and Lactococcus lactis to improve metabolic parameters and Lactococcus lactis in preventing inflammation and the hepatic diseases development.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofMolecular Biology Reports-
dc.rightsAcesso Restritopt_BR
dc.subject.otherPolifenóispt_BR
dc.subject.otherInflamaçãopt_BR
dc.subject.otherFígado - Doençaspt_BR
dc.titleAcute oral treatment with resveratrol and Lactococcus Lactis Subsp. Lactis decrease body weight and improve liver proinflammatory markers in C57BL/6 micept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s11033-021-06190-7pt_BR
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