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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/52791
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dc.creatorEloá Mangabeira Santospt_BR
dc.creatorCarlos Alberto de Carvalho Fragapt_BR
dc.creatorAlessandra Rejane Ericsson de Oliveira Xavierpt_BR
dc.creatorMauro Aparecido de Souza Xavierpt_BR
dc.creatorMarcela Gonçalves Souzapt_BR
dc.creatorSabrina Ferreira de Jesuspt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorLucyana Conceição Fariaspt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.creatorTiago Góss dos Santospt_BR
dc.creatorFlávio Henrique Beraldo de Paivapt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.date.accessioned2023-05-04T12:10:06Z-
dc.date.available2023-05-04T12:10:06Z-
dc.date.issued2021-04-25-
dc.citation.volume50pt_BR
dc.citation.spage985pt_BR
dc.citation.epage994pt_BR
dc.identifier.doi10.1111/jop.13188pt_BR
dc.identifier.issn1600-0714pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/52791-
dc.description.resumoBackground: head and neck squamous cell carcinoma (HNSC) etiopathogenesis remains unclear, and the biological changes with the activation of heat shock proteins (HSPs) and prion protein (PRNP) promoted by hypoxia in HNSC are undetermined. This study investigates hypoxia's effect in lymph node metastasis by PRNP expression changes and its main partners. Methods: the study combined a theoretical/cell culture study with a case-control study. First, bioinformatics and cell culture were performed. A case-control study was performed in a second step by comparing HNSC patients with and without lymph node metastasis. Analyses: the Cancer Genome Atlas (TCGA) data source validates the theory in the global population study. Results: bioinformatics analysis suggests that hypoxia-inducible factor-1α (HIF1A) is associated with HSPA4, HSP90AA1 and PRNP expression. TCGA data validate the hypothesis that higher HSP90AA1, HSPA4 and PRNP are related to metastases and low survival. Herein, the cell study demonstrated that muted PRNP did not respond to hypoxia. Discussion: our results collectively provide the first evidence that PRNP promotes HNSC lymph node metastasis progression through the upregulation of HSPA4, HSP90AA1 and HIF1A. Our findings may provide a molecular basis for the promoting Role of PRNP in HNSC progression.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Oral Pathology and Medicine-
dc.rightsAcesso Restritopt_BR
dc.subject.otherCâncerpt_BR
dc.subject.otherPríon - Doençaspt_BR
dc.subject.otherMetástasept_BR
dc.subject.otherBioinformáticapt_BR
dc.titlePrion protein is associated with a worse prognosis of head and neck squamous cell carcinomapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/full/10.1111/jop.13188pt_BR
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