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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/52847
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dc.creatorNatália Gonçalves Ribeiropt_BR
dc.creatorFabio Ribeiro dos Santospt_BR
dc.creatorJanaína Ribeiro Oliveirapt_BR
dc.creatorAmanda Souto Machadopt_BR
dc.creatorDeborah de Faria Lelispt_BR
dc.creatorAlfredo Maurício Batista de Paulapt_BR
dc.creatorAndré Luís Sena Guimarãespt_BR
dc.creatorLucyana Conceição Fariaspt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.date.accessioned2023-05-05T12:49:44Z-
dc.date.available2023-05-05T12:49:44Z-
dc.date.issued2021-01-27-
dc.citation.volume28pt_BR
dc.citation.spage781pt_BR
dc.citation.epage787pt_BR
dc.identifier.doi10.2174/0929866528666210127151803pt_BR
dc.identifier.issn1875-5305pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/52847-
dc.description.resumoBackground: brazilian flora is rich in plants with medicinal properties, which though popular, has contributed to the development of a range of phytotherapic products that use plants to treat and cure diseases. However, studies that use Brazilian plants in the treatment of metabolic disorders are still scarce in the literature. Objective: the aim of this study was to analyze the effect of hepatotoxicity Lafoensia pacari on the metabolism of mice with obesity induced by a high-fat diet and to verify the phytochemical difference between the Lafoensia pacari bark of the trunk, leaves, and branches. Methods: the plant material was collected from April to May in the municipality of Bonito de Minas, MG, Brazil. Qualitative tests for the presence of secondary metabolite classes were performed for leaves, branches and bark of the trunk. Through histological analysis, we evaluated hepatocytes and cell lesions in the liver. Results: the comparative phytochemical analysis of the plant did not reveal alterations between the different plant parts. The phytochemical test showed that is preferable to use the leaves to make the extract to be applied, aiming to reduce the plant aggression. After treatment, greater changes were observed in the animals that received the high-fat diet and the hydroethanolic extract; the levels of AST, ALT, albumin and creatinine that were increased, thus demonstrating a possible toxicity. There were no significant differences in body weight. In the histological analysis, the animals without plant treatment displayed decreased liver weight and reduction in the inflammatory infiltrate. Conclusion: we conclude that Lafoensia pacari should be better evaluated for oral consumption and may cause liver damage.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofProtein & Peptide Letters-
dc.rightsAcesso Restritopt_BR
dc.subject.otherMetabolismopt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherPlantas medicinaispt_BR
dc.subject.otherQuímica vegetalpt_BR
dc.subject.otherMatéria médica vegetalpt_BR
dc.subject.otherHepatotoxicologiapt_BR
dc.titleHepatotoxic effect of Lafoensia pacari A. St. Hil. (Lythraceae) on a diet-induced obese mice modelpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.eurekaselect.com/article/113729pt_BR
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