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Type:	Artigo de Periódico
Title:	30 years of experience with non-hodgkin lymphoma in children and adolescents: a retrospective cohort study
Authors:	Maria Christina L.oliveira Keyla Christy Christine Mendes Sampaio Cunha Andrea c. Brito Marcia k. Campos Mitiko Murao Rebeca Gusmão Ana Angélica l. Fernandes Marcos b. Viana
Abstract:	OBJECTIVE: Describe the clinical and demographic characteristics of pediatric patients with non-Hodgkin’s lymphoma (NHL) enrolled in a tertiary unit of Pediatric Hematology between 1982-2015. PATIENTS AND METHODS: A retrospective cohort study of 140 patients aged 16 years or less with NHL. Demographic characteristics, data on diagnosis, and outcomes were analyzed. The overall survival (OS) analysis and stratification by the most frequent histological subtypes were performed using the Kaplan-Meier method. RESULTS: One hundred and thirty-six patients with de novo NHL and four with NHL as a second malignancy were analyzed. The median age at diagnosis was 6.4 years (interquartile range, 4.2 to 11.1 years); 101 patients were males. Four patients had primary immunodeficiency, four had human immunodeficiency virus, two post-liver transplantation, and one had autoimmune lymphoproliferative syndrome. The most frequent histological type was NHL of mature B- cell (B-NHL-B; 67.1%), with Burkitt’s lymphoma being the most frequent subtype, and lymphoblastic lymphoma (LBL, 21.4%). The main clinical manifestation at the diagnosis was abdominal tumors (41.4%). During the follow-up time, 13 patients relapsed, but five of them reached a second remission. Thirty-five patients died, and 103 remained alive in clinical remission. No contact was possible for two patients. The OS at 5 years was 74.5% (± 3.8%). The OS estimated for patients with LBL, NHL-B, and the remaining was 80.4%±7.9%, 72.8%±4.7%, and 74.5%±11%, respectively (P = 0.58).
Subject:	Linfoma não Hodgkin Criança Estudos de Coortes
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	MED - DEPARTAMENTO DE PEDIATRIA MED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	10.1590/1806-9282.66.1.25
URI:	http://hdl.handle.net/1843/53129
Issue Date:	2020
metadata.dc.url.externa:	https://www.scielo.br/j/ramb/a/CyvkJjNvNywCL4M3dyqhwMx/?lang=en
metadata.dc.relation.ispartof:	Revista da Associação Médica Brasileira
Appears in Collections:	Artigo de Periódico

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