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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/53129
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dc.creatorMaria Christina L.oliveirapt_BR
dc.creatorKeyla Christy Christine Mendes Sampaio Cunhapt_BR
dc.creatorAndrea c. Britopt_BR
dc.creatorMarcia k. Campospt_BR
dc.creatorMitiko Muraopt_BR
dc.creatorRebeca Gusmãopt_BR
dc.creatorAna Angélica l. Fernandespt_BR
dc.creatorMarcos b. Vianapt_BR
dc.date.accessioned2023-05-11T20:16:09Z-
dc.date.available2023-05-11T20:16:09Z-
dc.date.issued2020-
dc.citation.volume66pt_BR
dc.citation.issue1pt_BR
dc.citation.spage25pt_BR
dc.citation.epage30pt_BR
dc.identifier.doi10.1590/1806-9282.66.1.25pt_BR
dc.identifier.issn18069282pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/53129-
dc.description.resumoOBJECTIVE: Describe the clinical and demographic characteristics of pediatric patients with non-Hodgkin’s lymphoma (NHL) enrolled in a tertiary unit of Pediatric Hematology between 1982-2015. PATIENTS AND METHODS: A retrospective cohort study of 140 patients aged 16 years or less with NHL. Demographic characteristics, data on diagnosis, and outcomes were analyzed. The overall survival (OS) analysis and stratification by the most frequent histological subtypes were performed using the Kaplan-Meier method. RESULTS: One hundred and thirty-six patients with de novo NHL and four with NHL as a second malignancy were analyzed. The median age at diagnosis was 6.4 years (interquartile range, 4.2 to 11.1 years); 101 patients were males. Four patients had primary immunodeficiency, four had human immunodeficiency virus, two post-liver transplantation, and one had autoimmune lymphoproliferative syndrome. The most frequent histological type was NHL of mature B- cell (B-NHL-B; 67.1%), with Burkitt’s lymphoma being the most frequent subtype, and lymphoblastic lymphoma (LBL, 21.4%). The main clinical manifestation at the diagnosis was abdominal tumors (41.4%). During the follow-up time, 13 patients relapsed, but five of them reached a second remission. Thirty-five patients died, and 103 remained alive in clinical remission. No contact was possible for two patients. The OS at 5 years was 74.5% (± 3.8%). The OS estimated for patients with LBL, NHL-B, and the remaining was 80.4%±7.9%, 72.8%±4.7%, and 74.5%±11%, respectively (P = 0.58).pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTARpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofRevista da Associação Médica Brasileira-
dc.rightsAcesso Abertopt_BR
dc.subjectLymphoma Non-Hodgkinpt_BR
dc.subjectChildpt_BR
dc.subjectCohort Studiespt_BR
dc.subject.otherLinfoma não Hodgkinpt_BR
dc.subject.otherCriançapt_BR
dc.subject.otherEstudos de Coortespt_BR
dc.title30 years of experience with non-hodgkin lymphoma in children and adolescents: a retrospective cohort studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/ramb/a/CyvkJjNvNywCL4M3dyqhwMx/?lang=enpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4049-4645pt_BR
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