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http://hdl.handle.net/1843/54163| Type: | Artigo de Periódico |
| Title: | Novel self-nanoemulsifying drug-delivery system enhances antileukemic properties of all- trans retinoic acid |
| Authors: | Gabriel Silva Marques Borges Maria Irene Yoshida Elaine Maria de Souza Fagundes Christian Fernandes Lucas Antônio Miranda Ferreira Micael de Oliveira Ferencs Cristina de Mello Gomide Loures Mostafa Abdellatif Abdelsalam Abdelrheem Fernanda Cristina Gontijo Evangelista Camila Campos Sales Pedro Henrique Reis da Silva Renata Barbosa de Oliveira Ângelo Malachias de Souza Adriano de Paula Sabino |
| Abstract: | All-trans retinoic acid (ATRA) shows erratic oral bioavailability when administered orally against leukemia, which can be solved through its incorporation in self-nanoemulsifying drug-delivery systems (SEDDS). The SEDDS developed contained a hydrophobic ion pair between benzathine (BZT) and ATRA and was enriched with tocotrienols by the input of a palm oil tocotrienol rich fraction (TRF) in its composition. Results: SEDDS-TRF-ATRA-BZT allowed the formation of emulsions with nanometric size that retained ATRA within their core after dispersion. Pharmacokinetic parameters after oral administration of SEDDS-TRF-ATRA-BZT in mice were improved compared with what was seen for an ATRA solution. Moreover, SEDDS-TRF-ATRA-BZT had improved activity against HL-60 cells compared with SEDDS without TRF. |
| Subject: | Leucemia Câncer |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA ICX - DEPARTAMENTO DE FÍSICA ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi-org.ez27.periodicos.capes.gov.br/10.2217/nnm-2020-0061 |
| URI: | http://hdl.handle.net/1843/54163 |
| Issue Date: | 2020 |
| metadata.dc.url.externa: | https://www-futuremedicine-com.ez27.periodicos.capes.gov.br/doi/epub/10.2217/nnm-2020-0061 |
| metadata.dc.relation.ispartof: | Nanomedicine |
| Appears in Collections: | Artigo de Periódico |
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