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http://hdl.handle.net/1843/54419| Type: | Artigo de Periódico |
| Title: | Development of a new model of actinic enteritis in rats using a cobalt-60 open source and a protection device as a collimator |
| Authors: | Vinícius Rodrigues Taranto Nunes Paula Vieira Teixeira Vidigal Márcio Tadeu Pereira Luís Carlos Duarte Ladeira Rafael Calvão Barbuto Ivana Duval-araujo |
| Abstract: | Purpose: To describe a new model of actinic enteritis that does not use radiotherapy machines. Methods: Sixteen Wistar rats were divided into four groups, consisting of four animals each: control (group A), two weeks after irradiation (group B), five weeks after irradiation (groupC) and eight weeks after irradiation (group D). Animals were given a 10Gy radiation from a Cobalt-60 natural source in a nuclear technology research center. Protections of the surrounding tissues were obtained through the usage of plumb devices with a hole in the center, which served as a collimator. We obtained irradiated and non-irradiated colons from each animal. Results: In group B we found an important inflammatory response in the irradiated colon, which appeared in a reduced way in group C and was minimal in group D, in which we found a relevant collagen submucosal deposition/fibrosis. In all groups, the non-irradiated colon had a lower pathological damage in comparison with the irradiated colon.Conclusion: We thus described an efficient and feasible technique for obtaining an animal model of actinic enteritis. |
| Subject: | Radioterapia Radiação Enterite Inflamação Fibrose Ratos |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | MED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL MED - DEPARTAMENTO DE CIRURGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | 10.1590/s0102-865020170040000007 |
| URI: | http://hdl.handle.net/1843/54419 |
| Issue Date: | 2017 |
| metadata.dc.url.externa: | http://dx.doi.org/10.1590/s0102-865020170040000007 |
| metadata.dc.relation.ispartof: | Acta Cirúrgica Brasileira |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Development of a new model of actinic enterits in rats using a cobalt 60 open source and a protection device as a collimator pdfa.pdf | 10.74 MB | Adobe PDF | View/Open |
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