1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/54421
Full metadata record
DC FieldValueLanguage
dc.creatorMoacyr Ferreira Júniorpt_BR
dc.creatorSérgio de Assis Batistapt_BR
dc.creatorRafael Calvão Barbutopt_BR
dc.creatorAdriana d Gomespt_BR
dc.creatorDulciene Maria de Magalhães Queirozpt_BR
dc.creatorIvana Duval Araújopt_BR
dc.creatorMarcelo Vidigal Caliaript_BR
dc.date.accessioned2023-06-02T21:26:47Z-
dc.date.available2023-06-02T21:26:47Z-
dc.date.issued2017-07-10-
dc.citation.volume5pt_BR
dc.citation.issue4pt_BR
dc.citation.spage1pt_BR
dc.citation.epage9pt_BR
dc.identifier.doiDOI: 10.9734/AJMAH/2017/3461pt_BR
dc.identifier.issn25468414pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/54421-
dc.description.resumoH. pylori infection is associated with gastritis, pre cancerous lesions, gastric cancer and changes in the protective layer of mucus. However, to our knowledge, there are no studies in humans or experimental models that relate the infection with H. pylori strains containing one or three phosphorylation sites of the CagA protein with the mucins of the protective layer of mucus. The aim of this study was to research the effects of infection with H. pylori strains containing one or three phosphorylation sites of CagA protein on the MUC1 and MUC5AC mucins of Mongolian gerbils (Meriones unguiculatus) gastric mucosa. Methods: Mongolian gerbils were inoculated with H. pylori isolates containing one or three EPIYA C phosphorylation sites. The control group consisted of uninfected animals receiving only Brucella broth. Gastric mucosa fragments were assessed by immunohistochemistry using rabbit monoclonal antibodies against MUC1 and MUC5AC. The fragments were then analyzed through a digital morphometric method. Results: From the control group of non-infected animals (CTRL) to the Cag A positive locci with 1 EPYIA C group (CagA1Ep) and Cag A positive locci with 3 EPYIA C group (CagA3EP) there was a progressive and significant reduction in the expression of both MUC1 (p=0.003) andMUC5AC (p=0.003) after 45 days of infection. This reduction was more prominent in the CagA3Ep group. Similar results were obtained six months post-infection, but the reduction in the MUC5AC (p=0.001) and MUC1 (p=0.001) expression was more intense. Conclusion: H. pylori strains containing more phosphorylation sites of the CagA protein are able to reduce with greater intensity the expression of MUC1 and MUC5AC.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CIRURGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTARpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAsian Journal of Medicine and Health-
dc.rightsAcesso Abertopt_BR
dc.subjectHelicobacter pyloript_BR
dc.subjectMucin-1pt_BR
dc.subjectMucin-5pt_BR
dc.subjectCagA proteinpt_BR
dc.subject.otherHelicobacter pyloript_BR
dc.subject.otherMucina--1pt_BR
dc.subject.otherMucina-5pt_BR
dc.titleHelicobacter pylori containing more phospphorylation sites of the caga protein induces greater reduction of gastric mucinspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journalajmah.com/index.php/AJMAH/article/view/144pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6488-734Xpt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
File Description SizeFormat 
Helicobacter pyloriContaining More Phosphorylation Sites of the CagA Protein Induces Greater Reduction of Gastric Mucins.pdf5.03 MBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.