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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/54836
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dc.creatorWilson de Melocruvinelpt_BR
dc.creatorFabiano de Almeida Britopt_BR
dc.creatorFernanda Bull Flumianpt_BR
dc.creatorGlaucielen Gomes da Silvapt_BR
dc.creatorJozelia Rêgopt_BR
dc.creatorLisiane Maria Ericoni Dos Anjospt_BR
dc.creatorNatasha Slhessarenkopt_BR
dc.creatorSandra Gofinet Pasotopt_BR
dc.creatorSuzane Pretti Figueiredo Nevespt_BR
dc.creatorValéria Valimpt_BR
dc.creatorWilton Silva Dos Santospt_BR
dc.creatorLuis Eduardo Coelho Andradept_BR
dc.creatorPaulo Luiz Carvalho Francescantoniopt_BR
dc.creatorCarlos Alberto Von Mühlenpt_BR
dc.creatorAlessandra Dellavancept_BR
dc.creatorAntônio Carlos Ximenespt_BR
dc.creatorCarlos David Bicharapt_BR
dc.creatorCleonice Buenopt_BR
dc.creatorCristóvão Luis Pitangueira Mangueirapt_BR
dc.creatorEloísa Bonfápt_BR
dc.date.accessioned2023-06-12T19:58:38Z-
dc.date.available2023-06-12T19:58:38Z-
dc.date.issued2019-
dc.citation.volume59pt_BR
dc.citation.issue29pt_BR
dc.citation.spage1pt_BR
dc.citation.epage11pt_BR
dc.identifier.doi10.1186/s42358-019-0069-5pt_BR
dc.identifier.issn25233106pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/54836-
dc.description.resumoBackground: The V Brazilian Consensus for determination of autoantibodies against cellular constituents on HEp-2 cells, held in Brasilia (DF, Brazil) on August 27, 2016, discussed the harmonization between the Brazilian Consensus on ANA (BCA) guidelines and the International Consensus on ANA Patterns (ICAP) recommendations (www.anapatterns.org). Initial guidelines were formulated by the group of Brazilian experts with the purpose of guiding and enabling Brazilian clinical laboratories to adopt recommendations and to provide a common standard for national and international consensuses. Mainbody: Twenty Brazilian researchers and experts from universities and clinical laboratories representing the various geographical regions of the country participated in the meeting. Three main topics were discussed, namely the harmonization between the BCA guidelines and latest recommendations of the ICAP initiative, the adjustment of the terminology and report on HEp-2 patterns, and a reassessment of quality assurance parameters. For the three topics, our aim was to establish specific guidelines. All recommendations were based on consensus among participants. There was concrete progress in the adjustment of the BCA guidelines to match the ICAP guidelines. To a certain extent, this derives from the fact that ICAP recommendations were largely based on the algorithm and recommendations of the IV Brazilian ANA Consensus, as consistently recognized in the ICAP publications and presentations. However, although there is great overlap between the two Consensuses, there are some point divergences. These specific items were individually and extensively discussed, and it was acknowledged that in several points ICAP improved recommendations previously issued by the Brazilian ANA Consensus and these changes were readily implemented. Regarding some specific topics, the BCA panel of experts felt that the previously issued recommendations remained relevant and possibly will require further discussion with ICAP. The term anti-cell antibodies was adopted as the recommended designation, recognizing that the assay addresses antibodies against antigens in the nucleus and in other cell compartments. However, the acronym ANA HEp-2 was maintained due to historical and regulatory reasons. It was also signalized that the latest trend in ICAP is to adopt the term Indirect Immunofluorescent Assay on HEp-2 cell substrate (HEp-2 IIFA). In addition, the quality assurance strategies previously presented were ratified and emphasized.Conclusion: The V BCA edition was successful in establishing an overall harmonization with the ICAP recommendations for interpretation of the HEp-2 IIFA test, pinpointing the perspectives in filling the remaining gaps between both initiatives.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTARpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAdvances in Rheumatology-
dc.rightsAcesso Abertopt_BR
dc.subjectANApt_BR
dc.subjectAutoantibodiespt_BR
dc.subjectHEp-2 cellspt_BR
dc.subjectAntinuclear antibodiespt_BR
dc.subjectIndirect immunofluorescencept_BR
dc.subjectStandardizationpt_BR
dc.subject.otherAutoanticorpospt_BR
dc.subject.otherCélulas Hep G2pt_BR
dc.subject.otherAnticorpos Antinuclearespt_BR
dc.subject.otherTécnica Indireta de Fluorescência para Anticorpopt_BR
dc.subject.otherPadrões de Referênciapt_BR
dc.titleV brazilian consensus guidelines for detection of anti-cell autoantibodies on hep-2 cellspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://advancesinrheumatology.biomedcentral.com/articles/10.1186/s42358-019-0069-5pt_BR
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