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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/54943
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dc.creatorTatiane Figueiredo Morais Papinipt_BR
dc.creatorCláudia Martins Carneiropt_BR
dc.creatorAndréa Teixeira Carvalhopt_BR
dc.creatorJordana Grazziela Alves Coelho Dos Reispt_BR
dc.creatorAna Paula Barbosa Wedlingpt_BR
dc.creatorLis Ribeiro do Vale Antonellipt_BR
dc.creatorPryscilla Fanini Wowkpt_BR
dc.creatorVânia Luiza Deperon Bonatopt_BR
dc.creatorValéria Maria Augustopt_BR
dc.creatorSilvana Maria Elói Santospt_BR
dc.creatorOlindo Assis Martins Filhopt_BR
dc.date.accessioned2023-06-14T20:43:40Z-
dc.date.available2023-06-14T20:43:40Z-
dc.date.issued2017-05-23-
dc.citation.volume222pt_BR
dc.citation.issue11pt_BR
dc.citation.spage1014pt_BR
dc.citation.epage1024pt_BR
dc.identifier.doi10.1016/j.imbio.2017.05.016pt_BR
dc.identifier.issn01712985pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/54943-
dc.description.resumoBackground: The lung lesions in an individual infected with tuberculosis (TB) are surprisingly variable and independent of each other. However, there is no circulating biomarker yet able to segregate patients according to the extent of lung lesions. Materials and methods: In this study, the phenotypic and functional profile of leukocytes of patients with active pulmonary tuberculosis (TB) and controls (CO) were fully scrutinized by immunophenotyping assays and in vitro short-term whole blood culture. The TB group was subdivided according to the extent of lung lesions as unilateral (UNI) and bilateral (BI). Results: The results show that TB group display an altered leukocyte profile in the peripheral blood with significant lower counts of NK-cells, CD3+CD56+CD16+/− NKT-cells, CD4+T-cells, CD19+B-cells when compared to CO. Increased CD4+T-cells and CD8+T-cell activation was observed by the upregulation of activation markers (HLA-DR) as well as of chemokine receptors (CCR2, CCR3, and CXCR4). In addition, TB group presented a significant decrease proportion of CD14LowCD16+ monocytes despite the increase in HLA-DR expression. Regarding the severity of the disease, in the BI group a reduction in frequency of CD19+CD5+ B-cells and expression of HLA-DR in CD14LowCD16+ monocytes was observed. Furthermore, the extent of lung lesions influences the production of molecules as observed by significantly larger production of IL-4 by neutrophils, total T-cells, CD4+T-cells, CD8+T-cells and CD19+B-cells in UNI as compared to BI. By contrast, in BI group the frequency of high producers of both IL-17+CD4+T-cells and IL-17+CD8+T-cells were significantly increased than UNI, suggesting the deleterious role of these subsets during active pulmonary Mtb infection. Conclusion: The immunophenotypic characterization of unilateral and bilateral active TB performed in the present study indicates that the extent of lung lesion could be associated with a fine-tuning between immunological responses during untreated Mtb infection.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofImmunobiology-
dc.rightsAcesso Restritopt_BR
dc.subjectTuberculosispt_BR
dc.subjectImmune responsept_BR
dc.subjectClinical outcomespt_BR
dc.subjectImmunophenotypingpt_BR
dc.subject.otherTuberculosept_BR
dc.subject.otherImunidadept_BR
dc.subject.otherResultado do Tratamentopt_BR
dc.subject.otherImunofenotipagempt_BR
dc.titleSystemic immunological changes in patients with distinct clinical outcomes during mycobacterium tuberculosis infectionpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0171298517300992?via%3Dihubpt_BR
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