Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/54977| Type: | Artigo de Periódico |
| Title: | Antioxidant activity and cytotoxicity effect of cocoa beans subjected to different processing conditions in human lung carcinoma cells |
| Other Titles: | Atividade antioxidante e efeito citotóxico de grãos de cacau submetidos a diferentes condições de processamento em célula de carcinoma de pulmão humano |
| Authors: | Deborah de Almeida Bauer Guimarães Joel Pimentel de Abreu Hilana Salete Silva Oliveira Aristóteles Góes Neto Maria Gabriela Bello Koblitz Anderson Junger Teodoro |
| Abstract: | Lung cancer is a common malignancy in men and the second leading cause of cancer-related mortality in men in the western world. Phenolic cocoa ingredients have a strong antioxidative activity and the potential to have a protective effect against cancer. In the present study, we have evaluated the influence of cocoa beans subjected to different processing conditions on cell viability and apoptosis of human lung cancer cells (A549). We measured the viability of lung cells treated with cocoa beans, unroasted slates (US), roasted slates (RS), unroasted well fermented (UWF) cocoa, and roasted well fermented (RWF) cocoa for 24 h. Using an MTT assay, we observed a decrease in the viability of A549 cells after treatment with cocoa bean extracts. Flow cytometer analysis revealed that cocoa beans increased the percentage of cells in sub-G1 phase and promoted up to twofold increase of apoptotic cells when compared to the control group. Taken together, the present study suggests that cocoa beans may have a protective effect against lung cancer. |
| Subject: | Antioxidantes Cacau Neoplasias Pulmonares |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE MICROBIOLOGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1155/2016/7428515 |
| URI: | http://hdl.handle.net/1843/54977 |
| Issue Date: | 2016 |
| metadata.dc.url.externa: | https://www.hindawi.com/journals/omcl/2016/7428515/ |
| metadata.dc.relation.ispartof: | Oxidative Medicine and Cellular Longevity |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Antioxidant activity and cytotoxicity effect of cocoa beans subjected to different processing conditions in human lung carcinoma cells .pdf | 21.69 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.