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Type:	Artigo de Periódico
Title:	Positively-charged electrosprayed nanoparticles based on biodegradable polymers containing amphotericin B for the treatment of leishmaniasis
Authors:	Manuela Maria de Sousa Messeder Diego Miranda Sarah Oliveira Lamas de Souza Matheus Figueiredo Dorneles Rodolfo Cordeiro Giunchetti Rodrigo Lambert Oréfice
Abstract:	Poly(Ɛ-caprolactone) (PCL) electrosprayed nanoparticles (NPs) containing Amphotericin B (AMB) were prepared for the treatment of leishmaniasis. Two variations of PCL nanoparticles with positive surface charges, which can enhance cell uptake and restrict agglomeration, were produced: (1) NPs containing stearylamine and (2) core-shell nanoparticles, with chitosan in the shell and PCL and AMB in the core. The results proved the viability of producing positively charged PCL nanoparticles with AMB, with diameters <350nm. The encapsulation efficiency of the drug was higher than 75%. The electrosprayed nanoparticles containing AMB were much less cytotoxic to cells than that of pure AMB.
Subject:	Anfotericina B. Leishmaniose Nanopartículas
language:	por
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ENG - DEPARTAMENTO DE ENGENHARIA METALÚRGICA ICB - DEPARTAMENTO DE MORFOLOGIA
Rights:	Acesso Restrito
metadata.dc.identifier.doi:	https://doi.org/10.1080/00914037.2020.1785457
URI:	http://hdl.handle.net/1843/54982
Issue Date:	2020
metadata.dc.url.externa:	https://www.tandfonline.com/doi/full/10.1080/00914037.2020.1785457
metadata.dc.relation.ispartof:	International Journal of Polymeric Materials and Polymeric Biomaterials
Appears in Collections:	Artigo de Periódico

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