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http://hdl.handle.net/1843/55031| Type: | Artigo de Periódico |
| Title: | Cell Division in genus Corynebacterium: protein-protein interaction and molecular docking of SepF and FtsZ in the understanding of cytokinesis in pathogenic species |
| Other Titles: | Divisão celular no gênero Corynebacterium: interação proteína-proteína e docking molecular de SepF e FtsZ no entendimento da citocinese em espécies patogênicas |
| Authors: | Alberto Fernandes de Oliveira Júnior Edson Luiz Folador Anne Cybelle Pinto Gomide Aristóteles Góes Neto Rebecca Alice Wattam Vasco Ariston de Carvalho Azevedo |
| Abstract: | The genus Corynebacterium includes species of great importance in medical, veterinary and biotechnological fields. The genus-specific families (PLfams) from PATRIC have been used to observe conserved proteins associated to all species. Our results showed a large number of conserved proteins that are associated with the cellular division process. Was not observe in our results other proteins like FtsA and ZapA that interact with FtsZ. Our findings point that SepF overlaps the function of this proteins explored by molecular docking, protein-protein interaction and sequence analysis. Transcriptomic analysis showed that these two (Sepf and FtsZ) proteins can be expressed in different conditions together. The work presents novelties on molecules participating in the cell division event, from the interaction of FtsZ and SepF, as new therapeutic targets. |
| Subject: | Divisão celular Corynebacterium Simulação de acoplamento molecular |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE MICROBIOLOGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | http://dx.doi.org/10.1590/0001-3765201820170385 |
| URI: | http://hdl.handle.net/1843/55031 |
| Issue Date: | 2017 |
| metadata.dc.url.externa: | https://www.scielo.br/j/aabc/a/QV8k6VjHz8XSzbp7dSjbM8H/?lang=en |
| metadata.dc.relation.ispartof: | Anais da Academia Brasileira de Ciências |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Cell Division in genus Corynebacterium_ protein-protein interaction and molecular docking of SepF and FtsZ in the understanding of cytokinesis in pathogenic species.pdf | 17.36 MB | Adobe PDF | View/Open |
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