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Type:	Artigo de Periódico
Title:	What is the level of evidence for the amnestic effects of sedatives in pediatric patients? A systematic review and meta-analyses
Authors:	Karolline Alves Viana Anelise Daher Lucianne Cople Maia Paulo Sucasas Costa Carolina de Castro Martins Saul Martins de Paiva Luciane Rezende Costa
Abstract:	Background: Studies have suggested that benzodiazepines are amnestic drug par excellence, but when taken together, what level of evidence do they generate? Are other sedatives as amnestic as benzodiazepines? The aim of this study was to assess the level of scientific evidence for the amnestic effect of sedatives in pediatric patients who undergo health procedures. Methods: The literature was searched to identify randomized controlled trials that evaluated anterograde and retrograde amnesia in 1-19-year-olds who received sedative drugs during health procedures. Electronic databases, including PubMed, Scopus and Cochrane Library besides clinical trial registries and grey literature were searched. Two independent reviewers performed data extraction and risk of bias assessment using the Cochrane Collaboration's Tool. The meta-analyses were performed by calculating relative risk (RR) to 95% confidence intervals (CI). The quality of the evidence was assessed using Grading of Recommendations Assessment, Development and Evaluation approach. Results: Fifty-four studies were included (4,168 participants). A higher occurrence of anterograde amnesia was observed when benzodiazepines, the most well-studied sedatives (n = 47), were used than when placebo was used (n = 12) (RR = 3.10; 95% CI: 2.30–4.19, P<0.001; I2 = 14%), with a moderate level of evidence. Higher doses of alpha2-adrenergic agonists (clonidine/dexmedetomidine) produced more anterograde amnesia than lower doses (n = 2) (RR = 1.83; 95% CI: 1.03–3.25; P = 0.038; I2 = 0%), with a low level of evidence; benzodiazepines’ amnestic effects were not dose-dependent (n = 3) (RR = 1.54; 95% CI: 0.96–2.49; P = 0.07; I2 = 12%) but the evidence was low. A qualitative analysis showed that retrograde amnesia did not occur in 8 out of 10 studies. Conclusions: In children, moderate evidence support that benzodiazepines induce anterograde amnesia, whereas the evidence for other sedatives is weak and based on isolated and small studies. Further clinical trials focused on the amnesia associated with non-benzodiazepine sedatives are therefore needed.
Subject:	Hypnotics and sedatives Amnesia Amnesia, retrograde Amnesia, anterograde Pediatric dentistry
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	FAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.1371/journal.pone.0180248
URI:	http://hdl.handle.net/1843/55035
Issue Date:	Jul-2017
metadata.dc.url.externa:	https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180248
metadata.dc.relation.ispartof:	PLOS ONE
Appears in Collections:	Artigo de Periódico

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