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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/55125
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Campo DCValorIdioma
dc.creatorAndrésalazarpt_BR
dc.creatorEduardo Paulino Júniorpt_BR
dc.creatorPaulo Guilherme o. Sallespt_BR
dc.creatorRaul Silva Filhopt_BR
dc.creatorEdna a. Reispt_BR
dc.creatorMarcelo Mamedept_BR
dc.date.accessioned2023-06-19T20:06:23Z-
dc.date.available2023-06-19T20:06:23Z-
dc.date.issued2018-08-24-
dc.citation.volume46pt_BR
dc.citation.issue4pt_BR
dc.citation.spage855pt_BR
dc.citation.epage863pt_BR
dc.identifier.doi10.1007/s00259-018-4128-7pt_BR
dc.identifier.issn16197070pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/55125-
dc.description.resumoPurpose Penile cancer (PC) is a rare neoplasm with an aggressive behavior and variable prognosis. Lymph node (LN) involvement and pathological features of the primary lesion have been proven to be the most important survival factors. Positron emission tomography/computed tomography with fluorodeoxyglucose labelled with fluorine-18 (18F-FDG PET/CT) provides information on tumor staging and works as a prognostic factor, with promising results in other carcinomas.The aim of the present study is to evaluate PET/CT as a prognostic factor in PC. Methods Fifty-five patients (mean age 56.6 y) diagnosed with penile squamous cell carcinoma were prospectively evaluated from 2012 to 2014. All subjects underwent 18F-FDG PET/CT before treatment and were regularly followed after surgery. Results Out of the 53 patients selected, 17 (32.1%) had localized disease (cT1–2) and 24 (45.3%) had palpable nodes (cN+). Partial penile amputation was performed in 38 patients (71.7%) and inguinal lymphadenectomy (LND) in 30 (56.6%). From the LND group, 16 (53.3%) presented with positive neoplastic cells (pN+). Patients with more aggressive disease had a significantly (p = 0.019) higher 18F-FDG tumor uptake (pSUVmax), while inguinal LN uptake (nSUVmax) was able to recognize metastatic LN (p = 0.039). Some pathological prognostic features, when presented, have shown significant changes in pSUVmax values. Receiver operating characteristic (ROC) curves were performed and specific cutoff values of pSUVmax were evaluated to determine sensitivity and specificity. Regarding regional LNs, PET/CT presented a 76.2% accuracy in cN+ patients. After a 39-month follow up, pSUVmax of 16.6 (p = 0.0001) and nSUVmax of 6.5 (p = 0.019) were established as the ideal values to predict cancer-specific survival. The multivariate analysis confirmed nSUVmax as a predictor for LN metastasis (p = 0.043) and pSUVmax as a mean to estimate survival rate (p = 0.05). Conclusion This study showed promising results on the use of 18F-FDG PET/CT as a prognostic tool for PC, using specific cut off values of pSUVmax and nSUVmax.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE ESTATÍSTICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA E IMAGEMpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofEuropean Journal of Nuclear Medicine and Molecular Imaging-
dc.rightsAcesso Abertopt_BR
dc.subjectPET/CTpt_BR
dc.subjectPenile cancerpt_BR
dc.subjectPrognostic valuept_BR
dc.subjectSurvivalpt_BR
dc.subject.otherTomografia por Emissão de Pósitrons combinada à Tomografia Computadorizadapt_BR
dc.subject.otherNeoplasias Penianaspt_BR
dc.subject.otherPrognósticopt_BR
dc.subject.otherAnálise de Sobrevidapt_BR
dc.title18F-FDG PET/CT as a prognostic factor in penile cancerpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s00259-018-4128-7pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6157-6511pt_BR
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