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http://hdl.handle.net/1843/55125| Tipo: | Artigo de Periódico |
| Título: | 18F-FDG PET/CT as a prognostic factor in penile cancer |
| Autor(es): | Andrésalazar Eduardo Paulino Júnior Paulo Guilherme o. Salles Raul Silva Filho Edna a. Reis Marcelo Mamede |
| Resumo: | Purpose Penile cancer (PC) is a rare neoplasm with an aggressive behavior and variable prognosis. Lymph node (LN) involvement and pathological features of the primary lesion have been proven to be the most important survival factors. Positron emission tomography/computed tomography with fluorodeoxyglucose labelled with fluorine-18 (18F-FDG PET/CT) provides information on tumor staging and works as a prognostic factor, with promising results in other carcinomas.The aim of the present study is to evaluate PET/CT as a prognostic factor in PC. Methods Fifty-five patients (mean age 56.6 y) diagnosed with penile squamous cell carcinoma were prospectively evaluated from 2012 to 2014. All subjects underwent 18F-FDG PET/CT before treatment and were regularly followed after surgery. Results Out of the 53 patients selected, 17 (32.1%) had localized disease (cT1–2) and 24 (45.3%) had palpable nodes (cN+). Partial penile amputation was performed in 38 patients (71.7%) and inguinal lymphadenectomy (LND) in 30 (56.6%). From the LND group, 16 (53.3%) presented with positive neoplastic cells (pN+). Patients with more aggressive disease had a significantly (p = 0.019) higher 18F-FDG tumor uptake (pSUVmax), while inguinal LN uptake (nSUVmax) was able to recognize metastatic LN (p = 0.039). Some pathological prognostic features, when presented, have shown significant changes in pSUVmax values. Receiver operating characteristic (ROC) curves were performed and specific cutoff values of pSUVmax were evaluated to determine sensitivity and specificity. Regarding regional LNs, PET/CT presented a 76.2% accuracy in cN+ patients. After a 39-month follow up, pSUVmax of 16.6 (p = 0.0001) and nSUVmax of 6.5 (p = 0.019) were established as the ideal values to predict cancer-specific survival. The multivariate analysis confirmed nSUVmax as a predictor for LN metastasis (p = 0.043) and pSUVmax as a mean to estimate survival rate (p = 0.05). Conclusion This study showed promising results on the use of 18F-FDG PET/CT as a prognostic tool for PC, using specific cut off values of pSUVmax and nSUVmax. |
| Assunto: | Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada Neoplasias Penianas Prognóstico Análise de Sobrevida |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | ICX - DEPARTAMENTO DE ESTATÍSTICA MED - DEPARTAMENTO DE ANATOMIA E IMAGEM MED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL |
| Tipo de Acesso: | Acesso Aberto |
| Identificador DOI: | 10.1007/s00259-018-4128-7 |
| URI: | http://hdl.handle.net/1843/55125 |
| Data do documento: | 24-Ago-2018 |
| metadata.dc.url.externa: | https://link.springer.com/article/10.1007/s00259-018-4128-7 |
| metadata.dc.relation.ispartof: | European Journal of Nuclear Medicine and Molecular Imaging |
| Aparece nas coleções: | Artigo de Periódico |
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| 18 F FDG PET CT as a prognostic factor in penile cancer pdfa.pdf | 629.43 kB | Adobe PDF | Visualizar/Abrir |
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