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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/55133
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dc.creatorJoão Paulo Lemosda Silveira Santospt_BR
dc.creatorCarla Jorge Machadopt_BR
dc.creatorEduardo Paulino Juniorpt_BR
dc.creatorJoão Bernardo Sancio Rocha Rodriguespt_BR
dc.creatorPaula Teixeira Vidigalpt_BR
dc.creatorVivian Resendept_BR
dc.date.accessioned2023-06-19T20:40:05Z-
dc.date.available2023-06-19T20:40:05Z-
dc.date.issued2018-05-07-
dc.citation.volume1pt_BR
dc.citation.spage1pt_BR
dc.citation.epage8pt_BR
dc.identifier.doihttps://10.1007/s11605-018-3797-7pt_BR
dc.identifier.issn1091255Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/55133-
dc.description.resumoObjectives To investigate immunohistochemical predictors for intestinal and pancreatobiliary types of adenocarcinoma of ampulla of Vater and identify clinicopathological characteristics associated with the histological types and patient survival. Methods Immunohistochemical markers included MUC1, MUC2, MUC5AC, CDX2, CK7, and CK20. The data were analyzed by univariate and multivariate methods. The two-step cluster method was used to determine the best immunohistochemical markers to discriminate the intestinal from the pancreatobiliary type. Results This study identified 9 (33.3%) intestinal and 21 (66.7%) pancreatobiliary tumors. CK7 and CDX2 achieved the highest value (= 1) as predictor markers, while CK20, MUC1, and MUC2 showed degrees of importance equal to 0.77, 0.71, and 0.68, respectively. MUC5AC did not reach 0.50 of importance. In the univariate analysis, lymph node involvement, staging (TNM), and angiolymphatic and perineural invasions were associated with histological types. The independent clinicopathological variable in the multivariate model to predict the histological type was angiolymphatic invasion (p = 0.005), OR = 17 (95% CI 2.33 to 123.83). The final model showed positive nodes (N1) associated with shorter survival (HR = 9.5; p = 0.006). Overallsurvival at 12, 36, and 60 months was 88.5, 67.0, and 47.6%, respectively. Conclusions CDX2 and CK7 were the immunohistochemical markers that best discriminated the intestinal from the pancreatobiliary type. Lymph node involvement had a high impact on survival and proved to be more frequent in the pancreatobiliary type.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGALpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CIRURGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Gastrointestinal Surgery-
dc.rightsAcesso Abertopt_BR
dc.subjectAmpulla of Vaterpt_BR
dc.subjectAdenocarcinomapt_BR
dc.subjectImmunohistochemistrypt_BR
dc.subjectSurvivalpt_BR
dc.subject.otherAmpola Hepatopancreáticapt_BR
dc.subject.otherAdenocarcinoma Sebáceopt_BR
dc.subject.otherImuno-Histoquímicapt_BR
dc.subject.otherSurvivalpt_BR
dc.titleImmunohistochemical predictors for intestinal and pancreatobiliary types of adenocarcinoma of the ampulla of vaterpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s11605-018-3797-7pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6157-6511pt_BR
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