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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/55134
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dc.creatorLeonardo do Pradolimapt_BR
dc.creatorCarla Jorge Machadopt_BR
dc.creatorJoão Bernardo Sancio Rocha Rodriguespt_BR
dc.creatorLeonardo de Souza Vasconcellospt_BR
dc.creatorEduardo Paulino Juniorpt_BR
dc.creatorPaula Vieira Teixeira Vidigalpt_BR
dc.creatorVivian Resendept_BR
dc.date.accessioned2023-06-19T20:53:54Z-
dc.date.available2023-06-19T20:53:54Z-
dc.date.issued2018-07-19-
dc.citation.volume2018pt_BR
dc.citation.spage1pt_BR
dc.citation.epage8pt_BR
dc.identifier.doi10.1155/2018/5970852pt_BR
dc.identifier.issn22912797pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/55134-
dc.description.resumoBackground and Aim. The epithelial cell adhesion molecule (EpCAM) has been proposed as a marker for cancer stem cells in human hepatocellular carcinoma (HCC) as well as in the development of novel target therapies. This study aimed to investigate the immunohistochemical expression of EpCAM and alpha-fetoprotein (AFP) in HCC patients and their association with clinicopathological characteristics. Methods. This study included Child-Pugh A HCC patients undergoing curative surgical resection. Results. A significant difference was observed in the ratio between the different phenotypes (p = 0.002), identifying 12 (29.3%) EPCAM positive tumors and 29 (70.7%) negative tumors. EpCAM+ expression was associated with AFP + (OR = 12.5, 95% CI, 1.9-84.1, p<0.001). In univariate analysis, a significant association was observed between AFP+ and EPCAM+ and the serum AFP level. A diameter of ≤ 5 cm was associated with EPCAM+, while angiolymphatic invasion was associated with APF+. In a multivariate analysis, only tumors of ≤ 5 cm were significantly associated with EpCAM+ (OR = 8.7; 95%CI, 1.27-100.0; p = 0.022). The overall survival rate was 74.9%, 69.4%, 69.4%, and 53.5% at 12, 24, 36, and 48 months, respectively. Conclusion. A considerable number of patients with EpCAM+ HCC would benefit from a specific target therapypt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGALpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CIRURGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIALpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTARpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofCanadian Journal of Gastroenterology and Hepatology-
dc.rightsAcesso Abertopt_BR
dc.subjectepithelial cell adhesion moleculept_BR
dc.subjectalpha-fetoproteinpt_BR
dc.subjectHepatocellular carcinomapt_BR
dc.subject.otherCarderinaspt_BR
dc.subject.otheralfa-Fetoproteínaspt_BR
dc.subject.otherCarcinoma Hepatocelularpt_BR
dc.titleImmunohistochemical coexpression of epithelial cell adhesion molecule and alpha-fetoprotein in hepatocellular carcinomapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.hindawi.com/journals/cjgh/2018/5970852/pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6157-6511pt_BR
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