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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/55143
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dc.creatorRaphael Costapt_BR
dc.creatorJoão Gabriel Silva Souzapt_BR
dc.creatorBruna e Nagaypt_BR
dc.creatorMartina Bertolinipt_BR
dc.creatorBarbara Emanuele Costa-Oliveirapt_BR
dc.creatorAline Araújo Sampaiopt_BR
dc.creatorBelén Retamal-Valdespt_BR
dc.creatorJamil Shiblipt_BR
dc.creatorMagda Ferespt_BR
dc.creatorValentim Adelino Ricardo Barãopt_BR
dc.date.accessioned2023-06-20T11:40:48Z-
dc.date.available2023-06-20T11:40:48Z-
dc.date.issued2021-
dc.citation.volume298pt_BR
dc.citation.spage102551pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.cis.2021.102551pt_BR
dc.identifier.issn00018686pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/55143-
dc.description.resumoPolymicrobial infection is the main cause of dental implant failure. Although numerous studies have reported the ability of titanium (Ti) surface modifications to inhibit microbial adhesion and biofilm accumulation, the majority of solutions for the utilization of Ti antibacterial surfaces have been testedin in vitro and animal models, with only a few developed surfaces progressing into clinical research. Motivated by this huge gap, we critically reviewed the scientific literature on the existing antibacterial Ti surfaces to help understand these surfaces' impact on the "puzzle" of undesirable dental implant-related infections. This manuscript comprises three main sections: (i) a narrative review on topics related to oral biofilm formation, bacterial-implant surface interactions, and on how implant-surface modifications can influence microbial accumulation; (ii) a critical evidence-based review to summarize pre-clinical and clinical studies in an attempt to "fit pieces into the puzzle" to unveil the best way to reduce microbial loads and control polymicrobial infection around dental implants showed by the current in vivo evidence; and (iii) discussion and recommendations for future research testing emerging antibacterial implant surfaces, connecting basic science and the requirements for future clinical translation. The findings of the present review suggest no consensus regarding the best available Ti surface to reduce bacterial colonization on dental implants. Smart release or on-demand activation surface coatings are a "new piece of the puzzle", which may be the most effective alternative for reducing microbial colonization on Ti surfaces, and future studies should focus on these technologiespt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAdvances in Colloid and Interface Sciencept_BR
dc.rightsAcesso Restritopt_BR
dc.subject.otherBiofilmspt_BR
dc.subject.otherDental implantspt_BR
dc.subject.otherInfectionspt_BR
dc.subject.otherTitaniumpt_BR
dc.subject.otherAnti-bacterial agentspt_BR
dc.titleFitting pieces into the puzzle: the impact of titanium-based dental implant surface modifications on bacterial accumulation and polymicrobial infectionspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S0001868621001925?via%3Dihubpt_BR
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