Use este identificador para citar o ir al link de este elemento:
http://hdl.handle.net/1843/55178| Tipo: | Artigo de Periódico |
| Título: | Individualized threshold for tumor segmentation in 18F-FDG PET/CT imaging: the key for response evaluation of neoadjuvant chemoradiation therapy in patients with rectal cancer? |
| Autor(es): | Theara C.fagundes Marcelo Mamede Arnoldo Mafra Rodrigo g. Silva Ana c. g. Castro Luciana c. Silva Priscilla t. Aguiar Josiane a. Silva Eduardo Paulino Júnior Alexei m. Machado |
| Resumen: | Introduction: The standard treatment for locally advanced rectal cancer (RC) consists of neoadjuvant chemoradiation followed by radical surgery. Regardless the extensive use of SUV max in 18F-FDG PET tumor uptake as representation of tumor glycolytic consumption, there is a trend to apply metabolic volume instead. Thus, the aim of the present study was to evaluate a noninvasive method for tumor segmentation using the 18F-FDG PET imaging in order to predict response to neoadjuvant chemoradiation therapy in patients with rectal cancer. Method: The sample consisted of stage II and III rectal cancer patients undergoing 18F-FDG PET/CT examination before and eight weeks after neoadjuvant therapy. An individualized tumor segmentation methodology was applied to generate tumor volumes (SUV2SD) and compare with standard SUVmax and fixed threshold (SUV40%, SUV50% and SUV60%) pre- and post-therapy. Therapeutic response was assessed in the resected specimens using Dworak’s protocol recommendations. Several variables were generated and compared with the histopathological results. Results: Seventeen (17) patients were included and analyzed. Significant differences were observed between responders (Dworak 3 and 4) and non-responders for SUVmax-2 (p<0.01), SUV2SD-2 (p<0.05), SUV40%-2 (p<0.05), SUV50%-2 (p<0.05) and SUV60%-2 (p<0.05). ROC analyses showed significant areas under the curve (p<0.01) for the proposed methodology with sensitivity and specificity varying from 60% to 83% and 73% to 82%, respectively. Conclusion: The present study confirmed the predictive power of the variables using a noninvasive individualized methodology for tumor segmentation based on 18F-FDG PET/CT imaging for response evaluation in patients with rectal cancer after neoadjuvant chemoradiation therapy. |
| Asunto: | Neoplasias Retais Terapia Neoadjuvante Fluordesoxiglucose F18 Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Institución: | UFMG |
| Departamento: | MED - DEPARTAMENTO DE ANATOMIA E IMAGEM MED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL |
| Tipo de acceso: | Acesso Aberto |
| Identificador DOI: | https://doi.org/10.1590/1806-9282.64.02.119 |
| URI: | http://hdl.handle.net/1843/55178 |
| Fecha del documento: | 17-jul-2017 |
| metadata.dc.url.externa: | https://www.scielo.br/j/ramb/a/ZxzXM5kmVRNzgzzSkXSL9BL/?lang=en |
| metadata.dc.relation.ispartof: | Revista da Associação Médica Brasileira |
| Aparece en las colecciones: | Artigo de Periódico |
archivos asociados a este elemento:
| archivo | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| Individualized threshold for tumor pdfa.pdf | 326.22 kB | Adobe PDF | Visualizar/Abrir |
Los elementos en el repositorio están protegidos por copyright, con todos los derechos reservados, salvo cuando es indicado lo contrario.