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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/55291
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dc.creatorAna Carolina Aguiar Vasconcelos Carneiropt_BR
dc.creatorRicardo Wagner Almeida Vitorpt_BR
dc.creatorOlindo Assis Martins-filhopt_BR
dc.creatorUfmg Congenital Toxoplasmosis Group Brazilian 'ufmg-ctbgpt_BR
dc.creatorJúlia Gatti Ladeia Costapt_BR
dc.creatorAnderson da Silva Machadopt_BR
dc.creatorGláucia Manzan Queiroz Andradept_BR
dc.creatorSamantha Ribeiro Bélapt_BR
dc.creatorJordana g. Coelho-dos-reispt_BR
dc.creatorEloísa A.v. Ferropt_BR
dc.creatorJosé Nélio Januáriopt_BR
dc.creatorAndréa Teixeira-carvalhopt_BR
dc.creatorDaniel Vitor Vasconcelos-santospt_BR
dc.date.accessioned2023-06-23T20:19:51Z-
dc.date.available2023-06-23T20:19:51Z-
dc.date.issued2016-03-05-
dc.citation.volume213pt_BR
dc.citation.issue12pt_BR
dc.citation.spage1962pt_BR
dc.citation.epage1970pt_BR
dc.identifier.doihttps://10.1093/infdis/jiw041pt_BR
dc.identifier.issn00221899pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/55291-
dc.description.resumoBackground. Ocular toxoplasmosis is a prominent and severe condition of high incidence in Brazil. The current study provides new insights into the immunological events that can be associated with retinochoroiditis in the setting of congenital toxoplasmosis in human infants. Methods. Flow cytometry of intracytoplasmic cytokines in leukocyte subsets following in vitro short-term antigenic recall in infants with congenital T. gondii infection. Results. Our data demonstrates that whereas neutrophils and monocytes from T. gondii–infected infants display a combination of proinflammatory and regulatory cytokine profiles, natural killer cells showed a predominantly proinflammatory profile upon in vitro T. gondii stimulation. The proinflammatory response of CD4+ and CD8+ T cells, characterized by the production of interferon γ (IFN-γ) and interleukin 17 in patients with an active retinochoroidal lesion, revealed the presence of IFN-γ and tumor necrosis factor α during early and late immunological events. This specific proinflammatory pattern is associated with early events and active retinochoroidal lesion, whereas a robust monocyte-derived interleukin 10–mediated profile is observed in children with cicatricial ocular lesions. Conclusions. These findings support the existence of a progressive immunological environment concomitant with the initial,apical, and cicatricial phases in the process of retinochoroidal lesion formation in infants with congenital toxoplasmosis that may be relevant in the establishment of stage-specific clinical management.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PARASITOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofThe Journal of Infectious Diseases-
dc.rightsAcesso Abertopt_BR
dc.subjectCongenital toxoplasmosispt_BR
dc.subjectCytokine profilept_BR
dc.subjectRetinochoroiditispt_BR
dc.subjectInfantspt_BR
dc.subjectActive and cicatricial lesionspt_BR
dc.subject.otherToxoplasmose Congênitapt_BR
dc.subject.otherCriançaspt_BR
dc.subject.otherCoriorretinopatia de Birdshotpt_BR
dc.titleCytokine signatures associated with early onset, active lesions and late cicatricial events of retinochoroidal commitment in infants with congenital toxoplasmosispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://academic.oup.com/jid/article/213/12/1962/2572144pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0912-3782pt_BR
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