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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/55297
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dc.creatorEricka Viana Machadocarellospt_BR
dc.creatorJuliana Queiroz de Andradept_BR
dc.creatorRoberta Maia Castro Romanellipt_BR
dc.creatorJacqueline Domingos Tibúrciopt_BR
dc.creatorJosé Nelio Januariopt_BR
dc.creatorDaniel Vítor Vasconcelos-santospt_BR
dc.creatorRosângela Maria Figueiredopt_BR
dc.creatorGláucia Manzan Queiroz de Andradept_BR
dc.date.accessioned2023-06-23T21:18:39Z-
dc.date.available2023-06-23T21:18:39Z-
dc.date.issued2017-12-
dc.citation.volume36pt_BR
dc.citation.issue12pt_BR
dc.citation.spage1169pt_BR
dc.citation.epage1176pt_BR
dc.identifier.doi10.1097/inf.0000000000001561pt_BR
dc.identifier.issn08913668pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/55297-
dc.description.resumoBackground: There are few studies reporting frequency and control of adverse events associated with congenital toxoplasmosis treatment. The objective of this study is to describe treatment adherence and adverse hematologic events in a cohort of children identified with congenital toxoplasmosis in Minas Gerais, Brazil.Methods: Children were treated with sulfadiazine, pyrimethamine and folinic acid and were evaluated clinically and by laboratory tests at regular intervals.Results: Of 146,307 live newborns who participated in the Neonatal Screen ing Program in Minas Gerais in 2006–2007, 190 had congenital toxoplasmosis. Among the 171 children whose treatment data were available, 73.1% completely adhered to antiparasitic therapy. Hematologic adverse events (macrocytic anemia and/or neutropenia and/or thrombocytopenia) were diagnosed in 44% of them. The most common adverse event was neutrope nia (31%). In most cases, it was not severe and reversed after increase in folinic acid dosage (25.7%) or temporary treatment suspension (1.8%). No infections were observed in association with neutropenic events. Significant associations were detected between macrocytic anemia and lower weight Z score at first medical appointment (P = 0.03), and between severe neutropenia (<500/mm3) and lower weight Z score toward the end of treatment (P = 0.04).Conclusions: The high frequency of hematologic adverse events found, especially in malnourished children, highlight the importance of careful monitoring of these children throughout treatment, as well as considering nutritional aspects and the need for higher doses of folinic acid. With adequate monitoring, antiparasitic treatment was feasible and relatively safe in the setting of this large screening program for congenital toxoplasmosispt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofThe Pediatric Infectious Disease Journal-
dc.rightsAcesso Restritopt_BR
dc.subjectToxoplasmosis/congenitalpt_BR
dc.subjectSulfadiazinept_BR
dc.subjectPyrimethaminept_BR
dc.subjectAdverse effectspt_BR
dc.subject.otherToxoplasmose Congênitapt_BR
dc.subject.otherSulfadiazinapt_BR
dc.subject.otherPirimetaminapt_BR
dc.titleHigh frequency of bone marrow depression during congenital toxoplasmosis therapy in a cohort of children identified by neonatal screening in minas gerais, brazilpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.lww.com/pidj/Fulltext/2017/12000/High_Frequency_of_Bone_Marrow_Depression_During.21.aspxpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0912-3782pt_BR
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