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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/55309
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dc.creatorDriele Tavarespt_BR
dc.creatorMarcelo Gustavo Paulinopt_BR
dc.creatorAna Paula Terezanpt_BR
dc.creatorJoão Batista Fernandespt_BR
dc.creatorAlessandra Gianipt_BR
dc.creatorMarisa Narciso Fernandespt_BR
dc.date.accessioned2023-06-23T22:59:36Z-
dc.date.available2023-06-23T22:59:36Z-
dc.date.issued2019-
dc.citation.volume216pt_BR
dc.citation.spage1pt_BR
dc.citation.epage10pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.aquatox.2019.105315pt_BR
dc.identifier.issn1879-1514pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/55309-
dc.description.resumoBlooms of cyanobacteria, a common event in eutrophic environments, result in the release of potentially toxic substances into the water. The cyanobacterium Radiocystis fernandoi produces microcystin (MC) and other peptides that may disturb homeostasis. This study evaluated the effect of intraperitoneal injections containing the crude extract (CE) of R. fernandoi strain R28 on the gills and kidneys of neotropical fish, Piaractus mesopotamicus, 3, 6 and 24 h post-injection. CE contained MC-RR, MC-YR and minor other oligopeptides. Plasma ions and the activities of the enzymes PP1 and PP2A, Na+/K+-ATPase (NKA), H+-ATPase (HA) and carbonic anhydrase (CA) were determined and morphological changes in both the gills and kidneys were characterized. Compared to controls, the concentration of Na+ within the plasma of P. mesopotamicus decreased after treatment with CE 3 h post treatment and increased after 24 h; the concentration of K+ decreased after 6 h. The activity of the endogenous PP1 and PP2A was unchanged in the gills and was inhibited in the kidneys 6 h after i.p. injection. In the gills, NKA activity increased after 3 h and decreased 6 h post i.p. exposure. Further, NKA activity did not differ from the controls 24-h post injection. In the kidneys, NKA, HA and CA activities were unaffected by treatment. The mitochondria-rich cell (MRC) density in the gills decreased after 3 h in the filament and 3 and 6 h in the lamellae and was restored to the control levels 24 h post-exposure. Filament epithelial hyperplasia and hypertrophy, lamellar atrophy and rupture of the lamellar epithelium were the most common effects of treatment in the gills. No histopathological changes occurred in the kidneys. This study demonstrates that a single dose of toxic CE from R. fernandoi can cause a transitory ion imbalance in P. mesopotamicus which is related to the changes in MRC levels and NKA activity. Ionic balance was recovered 24 h post i.p. injection, however, morphological changes that occurred in the gills took a longer amount of time to return to normal. To conclude, the effects of components contained within the CE of R. fernandoi may be harmful to P. mesopotamicus. In particular, the recovery of ionic regulation depends on MRC responses and histopathological changes produced by CE may affect gas exchange and other gill functions.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BOTÂNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAquatic Toxicologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectMicrocystinpt_BR
dc.subjectNa+/K+-ATPasept_BR
dc.subjectH+ ATPasept_BR
dc.subjectCarbonicanhydrasept_BR
dc.subjectMitochondria-richcellspt_BR
dc.subjectHistopathologypt_BR
dc.subject.otherSodio/potassio ATPasept_BR
dc.subject.otherAnidrase carbonicapt_BR
dc.subject.otherEquilibrio ionicopt_BR
dc.titleOsmoregulatory disturbance in Neotropical fish exposed to the crude extracts of the cyanobacterium, Radiocystis fernandoipt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0166445X1930445X?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0464-6848pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6864-887Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2924-3327pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2524-8534pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1331-1356pt_BR
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