A influência do eixo cérebro-intestino nas alterações alimentares envolvendo o transtorno de compulsão alimentar

Abstract

This research work is an integrative literature review that focuses on possible relationship between intestinal dysbiosis and changes in eating behavior associated with Binge Eating Disorder (BED) in humans. Thus, we sought to characterize and identify evidence from the literature that corroborate these relationships and hypothesize about how the pattern of intestinal dysbiosis associated with this eating disorder could contribute to changes in eating behavior. To achieve these objectives, studies by BRETON et al. (2016) and TENNOUNE et al. (2014), which approach plasma concentrations of caseinolytic peptidase B (ClpB) in individuals with eating disorders, by LEYROLLE et al. (2020), who performed a sequencing of the intestinal microbiota of obese individuals with or without Binge Eating Disorder and CARLOS et al. (2022), who conducted a study with the administration of two types of probiotics in patients after bariatric surgery. Through this research, the role of ClpB as a potential modulator of pathophysiological contribution was evidenced, since, in rodents, ClpB is capable of directly activating anorectic hypothalamic stimulators, in such a way, reduction in food intake and possible beneficial effects in Binge Eating Disorder treatment. Although the works listed in the present study suggest that potential alterations of dysbiosis may be present in the BED, it is necessary to emphasize that the evidence justified so far has important restrictions, not allowing an accurate analysis of the prescribed data and the establishment of standards, as planned in the objectives listed in this work. In addition, this research allows us to observe that there is still little evidence to support the fact that dysbiosis may be associated with changes in eating behavior in BED, despite the assembled studies dealing with this relationship. In addition, in this research, it was concluded that the pattern of dysbiosis in individuals with BED is not yet known, as well as whether interventions for modulating the microbiota would be effective in reducing behavioral changes.