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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/55773
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dc.creatorSarahtaimurpt_BR
dc.creatorEmily Blumbergpt_BR
dc.creatorMichael j. Satlinpt_BR
dc.creatorLarissa Pisneypt_BR
dc.creatorWanessa Trindade Clementept_BR
dc.creatorMarcus j. Zervospt_BR
dc.creatorRicardo m. la Hozpt_BR
dc.creatorShirish Huprikarpt_BR
dc.creatorStephanie m. Pouchpt_BR
dc.creatorNicole Zubizarretapt_BR
dc.creatorMadhu Mazumdarpt_BR
dc.creatorMeenakshi Ranapt_BR
dc.creatorGopi Patelpt_BR
dc.creatorMaristela Pinnheiro Freirept_BR
dc.creatorRebecca Pellett Madanpt_BR
dc.creatorEun Jeong Kwakpt_BR
dc.date.accessioned2023-07-04T19:55:43Z-
dc.date.available2023-07-04T19:55:43Z-
dc.date.issued2021-
dc.citation.volume35pt_BR
dc.citation.issue4pt_BR
dc.citation.spage1pt_BR
dc.citation.epage7pt_BR
dc.identifier.doi10.1111/ctr.14239pt_BR
dc.identifier.issn09020063pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/55773-
dc.description.resumoThe impact of pre-transplant (SOT) carbapenem-resistant Enterobacterales (CRE) colo nization or infection on post-SOT outcomes is unclear. We conducted a multi-center, international, cohort study of SOT recipients, with microbiologically diagnosed CRE colonization and/or infection pre-SOT. Sixty adult SOT recipients were included (livern = 30, hearts n = 17). Klebsiella pneumoniae (n = 47, 78%) was the most common pre SOT CRE species. Median time from CRE detection to SOT was 2.32 months (IQR 0.33–10.13). Post-SOT CRE infection occurred in 40% (n = 24/60), at a median of 9 days (IQR 7–17), and most commonly due to K pneumoniae (n = 20/24, 83%). Of those infected, 62% had a surgical site infection, and 46% had bloodstream infection.Patients with post-SOT CRE infection more commonly had a liver transplant (16, 67%vs. 14, 39%; p =.0350) or pre-SOT CRE BSI (11, 46% vs. 7, 19%; p =.03). One-year post-SOT survival was 77%, and those with post-SOT CRE infection had a 50% less chance of survival vs. uninfected (0.86, 95% CI, 0.76–0.97 vs. 0.34, 95% CI 0.08–1.0, p =.0204). Pre-SOT CRE infection or colonization is not an absolute contraindication to SOT and is more common among abdominal SOT recipients, those with pre-SOT CRE BSI, and those with early post-SOT medical and surgical complications.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTARpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofClinical Transplantation-
dc.rightsAcesso Restritopt_BR
dc.subjectCarbapenem-resistant enterobacteralespt_BR
dc.subjectMultidrug-resistan organismspt_BR
dc.subjectSolid organ transplantationpt_BR
dc.subject.otherKlebsiella pneumoniaept_BR
dc.subject.otherTransplante de orgãospt_BR
dc.titleImpact of pre-transplant carbapenem-resistant enterobacterales colonization and/or infection on solid organ transplant outcomespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/ctr.14239pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0848-3740pt_BR
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