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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/55781
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dc.creatorNicolas j Mullerpt_BR
dc.creatorOriol Manuelpt_BR
dc.creatorHande Arslanpt_BR
dc.creatorImran Hasanoglupt_BR
dc.creatorMaria López Olivapt_BR
dc.creatorSheila Chiesept_BR
dc.creatorNicola Duccio Salernopt_BR
dc.creatorOlivier Lortholarypt_BR
dc.creatorMical Paulpt_BR
dc.creatorAnne Scemlapt_BR
dc.creatorElisa Grazia Calvipt_BR
dc.creatorLaurent Dewispelaerept_BR
dc.creatorPaulo Henrique Orlandi Mourãopt_BR
dc.creatorAthina Pyrpasopouloupt_BR
dc.creatorIordanis Romiopoulospt_BR
dc.creatorElias Iosifidispt_BR
dc.creatorEdson Abdalapt_BR
dc.creatorMarta Bodropt_BR
dc.creatorTania Mara Varejão Strabellipt_BR
dc.creatorNoa Cohen'sinaipt_BR
dc.creatorMaría Carmen Fariñaspt_BR
dc.creatorWarren Lowmanpt_BR
dc.creatorMarco Falconept_BR
dc.creatorEsra Kazakpt_BR
dc.creatorMario Tumbarellopt_BR
dc.creatorErika Leasept_BR
dc.creatorNina Nestorovapt_BR
dc.creatorLigia C.pierrottipt_BR
dc.creatorFrancisco López'medranopt_BR
dc.creatorRafael San'juanpt_BR
dc.creatorMiguel Montejopt_BR
dc.creatorMaristela p. Freirept_BR
dc.creatorElisa Corderopt_BR
dc.creatorMiruna d. Davidpt_BR
dc.creatorEsperanza Merinopt_BR
dc.creatorSeema Mehta Steinkept_BR
dc.creatorPaolo a. Grossipt_BR
dc.creatorÁngela Canopt_BR
dc.creatorElena Pérez'nadalespt_BR
dc.creatorElena m. Seminaript_BR
dc.creatorMaricela Valeriopt_BR
dc.creatorFiliz Gunserenpt_BR
dc.creatorMeenakshi Ranapt_BR
dc.creatorAlessandra Mularonipt_BR
dc.creatorPilar Martín'dávilapt_BR
dc.creatorChristian Deldenpt_BR
dc.creatorMelike Hamiyet Demirkayapt_BR
dc.creatorZeliha Koçak Tufanpt_BR
dc.creatorBelén Loechespt_BR
dc.creatorMario Fernández'ruizpt_BR
dc.creatorRanganathan n. Iyerpt_BR
dc.creatorFabio Soldanipt_BR
dc.creatorBritt'marie Erikssonpt_BR
dc.creatorBenoît Pilmispt_BR
dc.creatorMarco Rizzipt_BR
dc.creatorJulien Coussementpt_BR
dc.creatorWanessa Trindade Clementept_BR
dc.creatorEmmanuel Roilidespt_BR
dc.creatorÁlvaro Pascualpt_BR
dc.creatorLuis Martínez'martínezpt_BR
dc.creatorBelén Gutiérrez'gutiérrezpt_BR
dc.creatorJesús Rodríguez'bañopt_BR
dc.creatorJulian Torre'cisnerospt_BR
dc.creatorJosé María Aguadopt_BR
dc.creatorTerence yi Shern Keept_BR
dc.creatorNúria Sabépt_BR
dc.creatorMariana Camoezpt_BR
dc.creatorMaría a Domínguezpt_BR
dc.creatorFidi Koppelpt_BR
dc.creatorJaime Lora'tamayopt_BR
dc.creatorLeyre Lopez'soriapt_BR
dc.creatorBan Hock Tanpt_BR
dc.creatorElias David'netopt_BR
dc.creatorFlávio Jota de Paula e Flávia Rossipt_BR
dc.creatorJose Antonio Lepept_BR
dc.creatorGabriel Bernal Blancopt_BR
dc.creatorCecilia Martín'gandulpt_BR
dc.creatorNoelia Balibreapt_BR
dc.creatorAntonio Francopt_BR
dc.creatorRobin Averypt_BR
dc.creatorDarin Ostranderpt_BR
dc.creatorDaniela Dalla Gasperinapt_BR
dc.creatorJordi Carratalàpt_BR
dc.creatorCristina Rovellipt_BR
dc.creatorAlejandra m Naterapt_BR
dc.creatorManuel Recio'rufiánpt_BR
dc.creatorJulia Guzmán'puchept_BR
dc.creatorCristina Leonipt_BR
dc.creatorPatricia Muñozpt_BR
dc.creatorCarlos Sánchez'carrillopt_BR
dc.creatorSara Lardopt_BR
dc.creatorDeena Rose Altmanpt_BR
dc.creatorJesús Fortúnpt_BR
dc.creatorIsabel Oriolpt_BR
dc.creatorRosa Escuderopt_BR
dc.creatorFrancesca Gioiapt_BR
dc.date.accessioned2023-07-04T20:46:10Z-
dc.date.available2023-07-04T20:46:10Z-
dc.date.issued2021-
dc.citation.volume23pt_BR
dc.citation.spage1pt_BR
dc.citation.epage16pt_BR
dc.identifier.doi10.1111/tid.13520pt_BR
dc.identifier.issn13982273pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/55781-
dc.description.resumoBackground: Whether active therapy with β-lactam/β-lactamase inhibitors (BLBLI) is as affective as carbapenems for extended spectrum β-lactamase-producing Enterobacterales (ESBL-E) bloodstream infection (BSI) secondary to urinary tract infection (UTI )in kidney transplant recipients (KTRs) remains unclear.Methods: We retrospectively evaluated 306 KTR admitted to 30 centers from January 2014 to October 2016. Therapeutic failure (lack of cure or clinical improvement and/or death from any cause) at days 7 and 30 from ESBL-E BSI onset was the primary and secondary study outcomes, respectively.Results: Therapeutic failure at days 7 and 30 occurred in 8.2% (25/306) and 13.4% (41/306) of patients. Hospital-acquired BSI (adjusted OR [aOR]: 4.10; 95% confidence interval [CI]: 1.50-11.20) and Pitt score (aOR: 1.47; 95% CI: 1.21-1.77) were independently associated with therapeutic failure at day 7. Age-adjusted Charlson Index (aOR: 1.25; 95% CI: 1.05-1.48), Pitt score (aOR: 1.72; 95% CI: 1.35-2.17), and lymphocyte count ≤500 cells/μL at presentation (aOR: 3.16; 95% CI: 1.42-7.06) predicted therapeutic failure at day 30. Carbapenem monotherapy (68.6%, primarily meropenem) was the most frequent active therapy, followed by BLBLI monotherapy (10.8%mostly piperacillin-tazobactam). Propensity score (PS)-adjusted models revealed no significant impact of the choice of active therapy (carbapenem-containing vs any other regimen, BLBLI- vs carbapenem-based monotherapy) within the first 72 hours on any of the study outcomes. Conclusions: Our data suggest that active therapy based on BLBLI may be as effective as carbapenem-containing regimens for ESBL-E BSI secondary to UTI in the specific population of KTR. Potential residual confounding and unpowered sample size cannot be excluded (ClinicalTrials.gov identifier: NCT02852902).pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTARpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofTransplant Infectious Disease-
dc.rightsAcesso Restritopt_BR
dc.subjectBloodstream infectionpt_BR
dc.subjectCarbapenem-sparing regimen,pt_BR
dc.subjectextended-spectrum β-lactamaseproducing Enterobacterales,pt_BR
dc.subjectKidney transplatationpt_BR
dc.subjectOutcomespt_BR
dc.subjectUrinary tract infecctionpt_BR
dc.subject.otherSepsept_BR
dc.subject.otherTransplante de rimpt_BR
dc.subject.otherResultado de tratamentopt_BR
dc.subject.otherInfecções Urináriaspt_BR
dc.titleEfficacy of β-lactam/β-lactamase inhibitors to treat extended-spectrum beta-lactamase-producing Enterobacterales bacteremia secondary to urinary tract infection in kidney transplant recipients (INCREMENT-SOT Project)pt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/tid.13520pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0848-3740pt_BR
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