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http://hdl.handle.net/1843/56036| Type: | Artigo de Periódico |
| Title: | Azithromycin for the treatment of eosinophilic nasal polyposis: clinical and histologic analysis |
| Authors: | Isamara Simasde Oliveira Paulo Fernando Tormin Borges Crosara Geovanni Dantas Cassali Diego Carlos Dos Reis Danilo Santana Rodrigues Flavio Barbosa Nunes Roberto Eustáquio Santos Guimarães |
| Abstract: | Introduction: Macrolides used as immunomodulators are a promising tool for chronic inflammatory airway diseases.Eosinophilic nasal polyposis (ENP) is still considered a disease that is difficult to control with the currently standardized treatments.Objectives: To evaluate prolonged treatment with low-dose azithromycin for ENP based on clinical and histopathologic variables.Methods: The present investigation was a self-paired case study of 33 patients with ENP. A comparison was performed between patients before and after treatment with azithromycin for 8 weeks. The patients were subjected to clinical examinations,staging (three-dimensional imaging by endoscopy), application of the questionnaire, and biopsy of nasal polyps at the beginning and at the end of the treatment. Results: The treatment yielded a clinical improvement regarding the two variables studied: polyposis staging (69.7%) and questionnaire (57.6%). We did not find significant differences in the inflammatory pattern and in the percentage or absolute number of eosinophils per field between samples obtained before and after the treatment (p > 0.05). There was no difference between the answers obtained from groups with and without asthma and/or aspirin intolerance (p>0.3). The patients with advanced initial staging exhibited lower subjective improvement index and staging reduction (p> 0.031 and p > 0.012, respectively). Conclusion: Based on this study, azithromycin may be considered as another therapeutic option for ENP. However, further studies are necessary to define the real mechanism of action involved. |
| Subject: | Macrolídeos Pólipos nasais Azitromicina Eosinófilos |
| language: | por |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE PATOLOGIA MED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.2500/ar.2016.7.0160 |
| URI: | http://hdl.handle.net/1843/56036 |
| Issue Date: | 2016 |
| metadata.dc.url.externa: | https://journals.sagepub.com/doi/full/10.2500/ar.2016.7.0160?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org |
| metadata.dc.relation.ispartof: | Therapeutic Advances in Allergy and Rhinology |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Azithromycin for the treatment of eosinophilic nasal pdfa.pdf | 111.15 kB | Adobe PDF | View/Open |
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