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http://hdl.handle.net/1843/56084| Type: | Artigo de Periódico |
| Title: | Effect of letrozole in carcinogen-plus-estrogen-induced endometrial hyperplasia in mice |
| Authors: | Alessandra Cerávololara Eduardo Batista Cândido Paula Vieira Vidigal Ana Luiza Lunardi Rocha Alessandra Costa Carvalho-macedo Marcia Mendonca Carneiro Agnaldo Lopes Silva-filho |
| Abstract: | PURPOSE: To evaluate the effects of letrozole (Ltz) in carcinogen+estrogen-induced endometrial hyperplasia. METHODS: BALB/c female mice were divided into four groups of 12 animals each receiving an intrauterine dose of N-ethyl-Nnitrosourea (ENU) and weekly subcutaneous injections of estradiol hexaidrobenzoate (EHB), except for group I(control). The groups were divided in I (control), II (ENU+EHB), III (ENU+EHB+MPA) and IV (ENU+EHB+Ltz). Group III also received intramuscular injections of MPA (medroxy progesterone acetate) every four weeks, while group IV received oral doses of Ltz daily. At the end of 16 weeks, the animals were sacrificed, and blood samples were collected for the measurement of serum estradiol and progesterone levels. Uterine histological sections were made to evaluate the presence of endometrial proliferative lesions. Differences between groups were evaluated with student’s t test, ANOVA and chi-square test.RESULTS: Groups ENU+EHB, ENU+EHB+MPA and ENU+EHB+Ltz showed varying degrees of endometrial hyperplasia. The incidence of hyperplasia in groups ENU+EHB and ENU+EHB+Ltz was higher and more severe than in group ENU+EHB+MPA. Control group showed lower levels of serum estradiol than the other groups. CONCLUSION: There was no evidence that letrozole could act as an antiestrogenic drug in the development of endometrial proliferative lesions. |
| Subject: | Hiperplasia Endometrial Estrogênio Neoplasias do Endométrio Letrozol |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | MED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL MED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | 10.1590/S0102-865020160040000010 |
| URI: | http://hdl.handle.net/1843/56084 |
| Issue Date: | 2016 |
| metadata.dc.url.externa: | https://www.scielo.br/j/acb/a/5Nxqg4tcxSRqhRFSK6HqJMB/?lang=en |
| metadata.dc.relation.ispartof: | Acta Cirúrgica Brasileira |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Effect of letrozole in carcinogen-plus-estrogen-induced endometrial hyperplasia in mice pdfa.pdf | 2.74 MB | Adobe PDF | View/Open |
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