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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56087
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dc.creatorLucas G.g.de Matospt_BR
dc.creatorEduardo Batista Cândidopt_BR
dc.creatorPaula V.t. Vidigalpt_BR
dc.creatorPolyanna H.c. Bordonipt_BR
dc.creatorRivia m. Lamaitapt_BR
dc.creatorMárcia m. Carneiropt_BR
dc.creatorAgnaldo l. da Silva-filhopt_BR
dc.date.accessioned2023-07-11T21:16:47Z-
dc.date.available2023-07-11T21:16:47Z-
dc.date.issued2016-11-15-
dc.citation.volume103pt_BR
dc.citation.issue1pt_BR
dc.citation.spage81pt_BR
dc.citation.epage86pt_BR
dc.identifier.doi10.5301/tj.5000576pt_BR
dc.identifier.issn03008916pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56087-
dc.description.resumoIntroduction: The immune system plays a critical role in the defense against human papillomavirus (HPV) infection and its persistence. Toll-like receptors (TLRs) are membrane receptors responsible for activation of the innate immune response, and an association between TLR expression and uterine cervical cancer has been shown. Tumor necrosis factors (TNFs) are among the main mediators of skin and mucosa inflammation. The aim of this study was to demonstrate the association between TLR and TNF immune expression and cervical cancer and premalignant cervical lesions.Methods: A total of 64 embedded tissues were obtained from gynecological procedures, including 35 specimens with cervical intraepithelial neoplasia (CIN) and 10 specimens with cervical squamous cell carcinoma (CSCC) as well as 19 normal cervical samples. The expression of TLR2, TLR3, TLR4, TNF-α and TNF-β was measured by immunohis tochemistry and graded into low and high levels of expression.Results: There was an association between the expression levels of TLR2 and those of TNF-α and TNF-β (p = 0.01 and p = 0.021, respectively) in the cervical cancer and CIN groups. TLR4 expression was associated with TNF-α and TNF-β expression (p = 0.016 and p = 0.025, respectively) in these 2 groups. By contrast, TLR3 was not statistically associated with TNF-α or TNF-β in any of the groups.Conclusions: There might be an association of the TLR2 and TLR4 pathways with the immunological response of TNF-α and TNF-β in cervical cancer. These markers are also expressed at higher levels in cervical cancer and premalignant lesions compared to normal controls.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofTumori Journal-
dc.rightsAcesso Restritopt_BR
dc.subjectCervical intraepithelial neoplasiapt_BR
dc.subjectImmune systempt_BR
dc.subjectImmunohistochemistrypt_BR
dc.subjectToll-like receptorspt_BR
dc.subjectTumor necrosis factorspt_BR
dc.subjectUterine cervical neoplasmspt_BR
dc.subject.otherDisplasia do Colo do Úteropt_BR
dc.subject.otherSistema Imunitáriopt_BR
dc.subject.otherImuno-Histoquímicapt_BR
dc.subject.otherReceptores Toll-Likept_BR
dc.subject.otherFatores de Necrose Tumoralpt_BR
dc.subject.otherNeoplasias do Colo do Úteropt_BR
dc.titleAssociation between toll-like receptor and tumor necrosis factor immunological pathways in uterine cervical neoplasmspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.sagepub.com/doi/full/10.5301/tj.5000576pt_BR
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