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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56146
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dc.creatorMaila de C. Nevespt_BR
dc.creatorDante G. Duartept_BR
dc.creatorMaicon R. Albuquerquept_BR
dc.creatorRodrigo Nicolatopt_BR
dc.creatorFernando Silva Nevespt_BR
dc.creatorFábio L. de Souza-Duranpt_BR
dc.creatorGeraldo Busattopt_BR
dc.creatorHumberto Corrêa da Silva Filhopt_BR
dc.date.accessioned2023-07-12T20:59:37Z-
dc.date.available2023-07-12T20:59:37Z-
dc.date.issued2016-
dc.citation.volume38pt_BR
dc.citation.issue1pt_BR
dc.citation.spage1pt_BR
dc.citation.epage5pt_BR
dc.identifier.doi10.1590/1516-4446-2014-1640pt_BR
dc.identifier.issn1809452Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56146-
dc.description.resumoObjective: Approximately one-half of all patients affected by bipolar disorder present with psychotic features on at least one occasion. Several studies have found that alterations in the activity of mesolimbic and prefrontal regions are related to aberrant salience in psychotic patients. The aim of the present study was to investigate the structural correlates of a history of hallucinations in a sample of euthymic patients with bipolar I disorder (BD-I).Methods: The sample consisted of 21 euthymic patients with BD-I and no comorbid axis I DSM-IV-TR disorders. Voxel based morphometry (VBM) was used to compare patients with and without a lifetime history of hallucinations. Preprocessing was performed using the Diffeomorphic Anatomical Registration through Exponentiated Lie Algebra (DARTEL) algorithm for VBM in SPM8. Images were processed using optimized VBM. Results: The main finding of the present study was a reduction in gray matter volume in the right posterior insular cortex of patients with BD-I and a lifetime history of hallucinations, as compared to subjects with the same diagnosis but no history of hallucinations. Conclusions: This finding supports the presence of abnormalities in the salience network in BD patients with a lifetime history of hallucinations. These alterations may be associated with an aberrant assignment of salience to the elements of one’s own experience, which could result in psychotic symptoms.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEEF - DEPARTAMENTO DE ESPORTESpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PSIQUIATRIA E NEUROLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofRevista Brasileira de Psiquiatria-
dc.rightsAcesso Abertopt_BR
dc.subjectBipolar disorderpt_BR
dc.subjectHallucinationspt_BR
dc.subjectSalience networkpt_BR
dc.subjectVoxel-based morphometrypt_BR
dc.subject.otherTranstorno Bipolarpt_BR
dc.subject.otherAlucinaçõespt_BR
dc.titleNeural correlates of hallucinations in bipolar disorderpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://doi:10.1590/1516-4446-2014-1640pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2757-1375pt_BR
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