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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56148
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dc.creatorPaulo Marcosbrasil Rochapt_BR
dc.creatorSimone Becho de Campospt_BR
dc.creatorFernando Silva Nevespt_BR
dc.creatorHumberto Corrêa da Silva Filhopt_BR
dc.date.accessioned2023-07-12T21:15:26Z-
dc.date.available2023-07-12T21:15:26Z-
dc.date.issued2017-
dc.citation.volume14pt_BR
dc.citation.issue5pt_BR
dc.citation.spage674pt_BR
dc.citation.epage680pt_BR
dc.identifier.doihttps://doi.org/10.4306/pi.2017.14.5.674pt_BR
dc.identifier.issn17383684pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56148-
dc.description.resumoObjectiveaaCircadian rhythms have been linked to psychiatric disorders such as Depression and Bipolar Disorder (BD). Given previous evidences of sleep/circadian disturbances as well as the genetic susceptibility for BD, we decided to investigate the possible link between the PERIOD3 (Per3) circadian gene and BD.Methods This is a genetic association case (BD) vs. control study of the Per3 gene. We further subdivided our BD sample into “good sleepers” (PSQI ≤5) and “poor sleepers” (PSQI>5) according to the Pittsburgh Sleep Quality Index (PSQI) global score, and then we asessed genetic association of the Per3 gene with sleep quality in the BD group. ResultsaaThere were 209 cases and 213 controls in our sample. The GT genotype of the SNP rs707467 significantly associated with BD (χ2=8.80; p-value=0.01; adjusted residual=±2.6). We also found significant association of the SNP rs10462020 allele T with BD (χ 2=5.81; p-value=0.01) as well as the genotype TT (χ2= 6.01; p-value=0.04; adjusted residual=±2.4). Conclusion: In this study we demonstrated evidences of genetic association between the Per3 gene and BD. The results of association between the Per3 gene and BD in our sample may bring additional evidence to the former findings of association between the Per3 gene and BD.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PSIQUIATRIA E NEUROLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofThe Psychiatry Investigation-
dc.rightsAcesso Abertopt_BR
dc.subjectBipolar disorderpt_BR
dc.subjectPERIOD3pt_BR
dc.subjectGenept_BR
dc.subjectCircadianpt_BR
dc.subjectBiological rhythmspt_BR
dc.subject.otherTranstorno Bipolarpt_BR
dc.subject.otherProteínas Circadianas Periodpt_BR
dc.subject.otherRelógios Circadianospt_BR
dc.subject.otherPeriodicidadept_BR
dc.titleGenetic Association of the PERIOD3 (Per3) Clock Gene with Bipolar Disorderpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.psychiatryinvestigation.org/journal/view.php?doi=10.4306/pi.2017.14.5.674-
dc.identifier.orcidhttps://orcid.org/0000-0003-2757-1375pt_BR
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