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Type:	Artigo de Periódico
Title:	Interleukin-10 promoter gene polymorphisms are associated with the first major depressive episode in chronic hepatitis C patients
Authors:	Luciana Rodrigues da Cunha Olindo Assis Martins Filho Dulciene Maria de Magalhães Queiroz Fernando Silva Neves Luciana Diniz Silva Diego Alves Vieira Yala Gramigna Giampietro Adriana Dias Gomes César Lúcio Lopes de Faria jr Fabrício Freire de Melo Rosângela Teixeira Andrea Teixeira de Carvalho Luciana Maria Oliveira Gifone Aguiar Rocha
Abstract:	Aims: To investigate the association of IL10 SNPs in chronic hepatitis C (CHC) patients with and without the first major depressive episode (MDE), as well as their association with plasma levelsof target cytokines. Methods: A hundred and thirty two CHC patients (32 with and 100 without first MDE) and 98 controls were prospectively enrolled in this cross-sectional study. MDE was diagnosed by a psy chiatrist, using the Mini International Neuropsychiatric Interview Plus 5.0. IL10 polymorphi (−1082G/A, −819C/T and −592C/A IL10 SNPs) were evaluated by Taqman SNP genotyping assay.Plasma concentrations of IL-2, IL-6, IL-10, IFN-y and TNF-a were determined using the HumanTh1/Th2 Cytometric Bead Array kit. The associations were investigated by logistic models.Results: The frequencies of the studied IL10 SNPs did not differ between the CHC patients and controls. The first MDE was positive and independently associated with the IL10-1082*A, IL10-819*T and IL10-592*A (ATA) low producer haplotype (OR = 1.50; 95% CI = 1.11—2.04; P = 0.009) and current alcohol misuse (OR = 4.29; 95% CI = 1.22—15.05; P = 0.02), and inversely associated with increasing age (OR = 0.94; 95% CI = 0.91—0.98; P = 0.006). In addition, plasma level of TNF- was significantly higher in the carriers than in the non-carriers of the IL10 ATA haplotype in patients with the first MDE. The IL-10 and IL-2 plasma levels were significantly higher in the carriers than in non carriers of the IL10 GCC high producer haplotype, demonstrating the functionality of the studied IL10 polymorphisms. Conclusions: This is the first study to demonstrate that the IL10 low producer ATA haplotype is associated with the first MDE in patients with CHC.
Subject:	Hepatite C Crônica Depressão Proteína Ribossômica L10
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	MED - DEPARTAMENTO DE CLÍNICA MÉDICA
Rights:	Acesso Restrito
metadata.dc.identifier.doi:	https://doi.org/10.1016/j.clinre.2018.11.015
URI:	http://hdl.handle.net/1843/56158
Issue Date:	24-Oct-2018
metadata.dc.url.externa:	https://www.sciencedirect.com/science/article/pii/S2210740118302766?via%3Dihub
metadata.dc.relation.ispartof:	Clinics and Research in Hepatology and Gastroenterology
Appears in Collections:	Artigo de Periódico

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