Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56161
Type: Artigo de Periódico
Title: The combined polymorphisms of interleukin-6-174GG genotype and interleukin-10 ATA haplotype are associated with a poor quality of life in patients with chronic hepatitis C
Authors: Diego Alves Vieira
Fabrício Freire de Melo
Dulciene Maria de Magalhães Queiroz
Luciana Diniz Silva
Luciana Rodrigues da Cunha
Cliviany Borges da Silva
Maria Thereza Bastos Almeida
Adriana Dias Gomes
César Lúcio Lopes de Faria
Rosângela Teixeira
Fernando Silva Neves
Gifone Aguiar Rocha
Abstract: Purpose Chronic hepatitis C (CHC) is associated with a decreased health-related quality of life (HRQOL). More recent studies have pointed toward a genetic basis of patient-reported quality of life outcomes. Taking into account that the influence of single-nucleotide polymorphisms (SNPs) on the HRQOL of CHC patients has not been studied, we investigated the combined IL10-1082G/A, − 819C/T, and − 592C/A SNPs, and IL6-174G/C SNP. We also evaluated the association between demo graphic, clinical, psychiatric, virological, and genetic variables with domains and summaries of HRQOL in CHC patients. Methods 132 consecutive CHC patients and 98 controls underwent psychiatric evaluation by using the Mini International Neuropsychiatric Interview. HRQOL was assessed by a generic questionnaire, the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), and by the specific Liver Disease Quality of Life Questionnaire (LDQOL). IL6 and IL10 poly morphisms were evaluated by Taqman SNP genotyping assay. Multivariate analysis was used to evaluate the associations. Results Major depressive disorder was associated with lower SF-36 and LDQOL scores in seven and ten domains, respec tively. Diabetes and hypertension were also associated with reduced HRQOL. CHC patients carrying the combination of IL10 ATA haplotype/IL6-GG genotype had lower scores in the SF-36—physical functioning domain, and reduced scores in the LDQOL effects of liver disease on activities of daily living, quality of social interaction, and sexual function domains than the non-carriers of the combined haplotype/genotype.Conclusion This is the first study to demonstrate that combined IL6 high-producer GG genotype and IL10 low-producer ATA haplotype is associated with poorer HRQOL in CHC patients.
Subject: Hepatite C Crônica
Qualidade de Vida
Interleucina-6
Interleucina-10
language: eng
metadata.dc.publisher.country: Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: MED - DEPARTAMENTO DE CLÍNICA MÉDICA
MED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR
Rights: Acesso Restrito
metadata.dc.identifier.doi: 10.1007/s11136-019-02129-5
URI: http://hdl.handle.net/1843/56161
Issue Date: 7-Feb-2019
metadata.dc.url.externa: https://link.springer.com/article/10.1007/s11136-019-02129-5
metadata.dc.relation.ispartof: Quality of Life Research
Appears in Collections:Artigo de Periódico

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