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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56254
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dc.creatorBruna Lima Costa Zuquim Nunanpt_BR
dc.creatorLucas Rios Drummondpt_BR
dc.creatorQuezia Teixeira Rodriguespt_BR
dc.creatorCarlos César Crestanipt_BR
dc.creatorRaphael Escorsim Szawkapt_BR
dc.creatorCândido Celso Coimbrapt_BR
dc.creatorGlauber dos Santos Ferreira da Silvapt_BR
dc.date.accessioned2023-07-14T19:31:39Z-
dc.date.available2023-07-14T19:31:39Z-
dc.date.issued2021-
dc.citation.volume177pt_BR
dc.citation.spage64pt_BR
dc.citation.epage72pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.brainresbull.2021.09.011pt_BR
dc.identifier.issn03619230pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56254-
dc.description.resumoThe paraventricular nucleus of the hypothalamus (PVN) is an important site for autonomic control, which integrates thermoregulation centers and sympathetic outflow to thermoeffector organs. PVN neurons express the neuronal isoform of nitric oxide synthase (nNOS) whose expression is locally upregulated by physical exercise. Thus, the aim of the present study was to evaluate the role of nNOS in the PVN in the exercise-induced hyperthermia. Seven days after surgery, male Wistar rats received bilateral intra-PVN microinjections of the selective nNOS inhibitor Nw-Propyl-L-Arginine (NPLA) or vehicle (saline) and were submitted to an acute progressive exercise session on a treadmill until fatigue. Abdominal and tail skin temperature (Tabd and Ttail, respectively) were measured, and the threshold (Hthr; °C) and sensitivity (Hsen) for heat dissipation calculated. Performance variables were also collected. During the progressive exercise protocol, all animals displayed an increase in the Tabd. However, compared to vehicle group, the microinjection of NPLA in the PVN attenuated the exercise-induced hyperthermia. There was no difference in Ttail or Hthr between NPLA and control rats. In contrast, Hsen was increased in the NPLA group compared to vehicle. In addition, heat storage was lower in NPLA-treated animals. Despite the temperature differences, inhibition of nNOS in the PVN did not affect running performance on the treadmill. These results suggest that nitrergic signaling within the PVN, under nNOS activation, drives the increase of body temperature, being necessary for the proper thermal regulatory mechanisms during progressive exercise-induced hyperthermia.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBrain Research Bulletinpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectExercise thermoregulationpt_BR
dc.subjectHypothalamuspt_BR
dc.subjectPVNpt_BR
dc.subjectNitric oxidept_BR
dc.subjectBody temperaturept_BR
dc.subjectPhysical performancept_BR
dc.subject.otherCorpo - Temperatura - Regulaçãopt_BR
dc.titleInhibition of nNOS in the paraventricular nucleus of hypothalamus decreases exercise-induced hyperthermiapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0361923021002744?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6042-7757pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3998-4169pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1942-858Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2639-3469pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8981-6724pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6269-7443pt_BR
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