1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56256
Full metadata record
DC FieldValueLanguage
dc.creatorVanessa Pereira Teixeirapt_BR
dc.creatorItamar Couto Guedes de Jesuspt_BR
dc.creatorAnderson Kenedy Santospt_BR
dc.creatorMauro de Oliveirapt_BR
dc.creatorRaphael Escorsim Szawkapt_BR
dc.creatorHelio Salgadopt_BR
dc.creatorMarco Antonio Máximo Pradopt_BR
dc.creatorMaristela Poletinipt_BR
dc.creatorSilvia Guatimosimpt_BR
dc.creatorKiany Mirandapt_BR
dc.creatorSergio Scalzopt_BR
dc.creatorCibele Rocha Resendept_BR
dc.creatorMário Morais Silvapt_BR
dc.creatorGeisa C. S. V. Tezinipt_BR
dc.creatorMarcos Melopt_BR
dc.creatorFernando Pedro Souza Netopt_BR
dc.creatorKaoma Silvapt_BR
dc.date.accessioned2023-07-14T19:33:18Z-
dc.date.available2023-07-14T19:33:18Z-
dc.date.issued2021-
dc.citation.volume320pt_BR
dc.citation.issue4pt_BR
dc.citation.spageC602pt_BR
dc.citation.epageC612pt_BR
dc.identifier.doihttps://doi.org/10.1152/ajpcell.00142.2020pt_BR
dc.identifier.issn0363-6143pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56256-
dc.description.resumoCholinesterase inhibitors are used in postmenopausal women for the treatment of neurodegenerative diseases. Despite their widespread use in the clinical practice, little is known about the impact of augmented cholinergic signaling on cardiac function under reduced estrogen conditions. To address this gap, we subjected a genetically engineered murine model of systemic vesicular acetylcholine transporter overexpression (Chat-ChR2) to ovariectomy and evaluated cardiac parameters. Left-ventricular function was similar between Chat-ChR2 and wild-type (WT) mice. Following ovariectomy, WT mice showed signs of cardiac hypertrophy. Conversely, ovariectomized (OVX) Chat-ChR2 mice evolved to cardiac dilation and failure. Transcript levels for cardiac stress markers atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) were similarly upregulated in WT/OVX and Chat-ChR2/OVX mice. 17b-Estradiol (E2) treatment normalized cardiac parameters in Chat-ChR2/OVX to the Chat-ChR2/SHAM levels, providing a link between E2 status and the aggravated cardiac response in this model. To investigate the cellular basis underlying the cardiac alterations, ventricular myocytes were isolated and their cellular area and contractility were assessed. Myocytes from WT/OVX mice were wider than WT/SHAM, an indicative of concentric hypertrophy, but their fractional shortening was similar. Conversely, Chat-ChR2/OVX myocytes were elongated and presented contractile dysfunction. E2 treatment again prevented the structural and functional changes in Chat-ChR2/OVX myocytes. We conclude that hypercholinergic mice under reduced estrogen conditions do not develop concentric hypertrophy, a critical compensatory adaptation, evolving toward cardiac dilation and failure. This study emphasizes the importance of understanding the consequences of cholinesterase inhibition, used clinically to treat dementia, for cardiac function in postmenopausal women.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAmerican Journal of Physiology-Cell Physiologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectCardiac dysfunctionpt_BR
dc.subjectCardiomyocytespt_BR
dc.subjectCholinergic signalingpt_BR
dc.subjectHypertrophypt_BR
dc.subject.otherCoraçãopt_BR
dc.subject.otherHipertrofiapt_BR
dc.titleIncreased cholinergic activity under conditions of low estrogen leads to adverse cardiac remodelingpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.physiology.org/doi/full/10.1152/ajpcell.00142.2020pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2510-7125pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5532-9813pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6185-3491pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2639-3469pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3028-5778pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7351-5740pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8386-3722pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4917-889Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7050-8040pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1496-878Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5109-0654pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6458-842Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4983-0681pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1990-5224pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.