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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56300
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dc.creatorVivian Vasconcelos Costapt_BR
dc.creatorJulia Maria S. Araújopt_BR
dc.creatorAllysson Cramerpt_BR
dc.creatorAna Luíza Campos Vila Realpt_BR
dc.creatorLucas Secchim Ribeiropt_BR
dc.creatorSilvia Ines Sardipt_BR
dc.creatorAnderson J. Ferreirapt_BR
dc.creatorFabiana Simão Machadopt_BR
dc.creatorAntônio Costa de Oliveirapt_BR
dc.creatorAntônio Lúcio Teixeirapt_BR
dc.creatorHelder Nakayapt_BR
dc.creatorDanielle da Glória de Souzapt_BR
dc.creatorFabiola M. Ribeiropt_BR
dc.creatorMauro Martins Teixeirapt_BR
dc.creatorRebeca de Paiva Froes Rochapt_BR
dc.creatorFlavia R. Silvapt_BR
dc.creatorJuliana G. Doriapt_BR
dc.creatorIsabella Guimarães Olmopt_BR
dc.creatorRafael Elias Marques Pereira Silvapt_BR
dc.creatorCelso Martins Queiroz Juniorpt_BR
dc.creatorGiselle Foureauxpt_BR
dc.creatorJuliana Lemos Del Sartopt_BR
dc.date.accessioned2023-07-14T20:36:05Z-
dc.date.available2023-07-14T20:36:05Z-
dc.date.issued2017-
dc.citation.issue8pt_BR
dc.citation.spage1pt_BR
dc.citation.epage16pt_BR
dc.identifier.doihttps://doi.org/10.1128/mbio.00350-17pt_BR
dc.identifier.issn2150-7511pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56300-
dc.description.resumoZika virus (ZIKV) infection is a global health emergency that causes significant neurodegeneration. Neurodegenerative processes may be exacerbated by N-methyl-D-aspartate receptor (NMDAR)-dependent neuronal excitoxicity. Here, we have exploited the hypothesis that ZIKV-induced neurodegeneration can be rescued by blocking NMDA overstimulation with memantine. Our results show that ZIKV actively replicates in primary neurons and that virus replication is directly associated with massive neuronal cell death. Interestingly, treatment with memantine or other NMDAR blockers, including dizocilpine (MK-801), agmatine sulfate, or ifenprodil, prevents neuronal death without interfering with the ability of ZIKV to replicate in these cells. Moreover, in vivo experiments demonstrate that therapeutic memantine treatment prevents the increase of intraocular pressure (IOP) induced by infection and massively reduces neurodegeneration and microgliosis in the brain of infected mice. Our results indicate that the blockade of NMDARs by memantine provides potent neuroprotective effects against ZIKV-induced neuronal damage, suggesting it could be a viable treatment for patients at risk for ZIKV infection-induced neurodegeneration.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAmerican Society for Microbiologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectNMDA receptorpt_BR
dc.subjectZika viruspt_BR
dc.subjectIntraocular pressurept_BR
dc.subjectMemantinept_BR
dc.subjectMicrogliosispt_BR
dc.subjectMouse modelpt_BR
dc.subjectNeuronal deathpt_BR
dc.subject.otherMedicinapt_BR
dc.subject.otherMicrobiologiapt_BR
dc.subject.otherPressão intra-ocularpt_BR
dc.titleN-Methyl-D-Aspartate (NMDA) Receptor Blockade Prevents Neuronal Death Induced by Zika Virus Infectionpt_BR
dc.typeArtigo de Eventopt_BR
dc.url.externahttps://journals.asm.org/doi/10.1128/mBio.00350-17pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0175-642Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5682-3773pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7751-3061pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8876-3827pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2002-8436pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8835-8071pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9621-5422pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5297-9108pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3432-0769pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7042-9433pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6944-3008pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5678-4006pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0007-3280pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6949-0947pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7463-6368pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6561-8018pt_BR
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