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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56309
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dc.creatorBruno Salomemoraispt_BR
dc.creatorAntonio Lucio Teixeira Juniorpt_BR
dc.creatorJader Freitas Macielpt_BR
dc.creatorAngela Aparecida Limapt_BR
dc.creatorIzabela Guimaraes Barbosapt_BR
dc.creatorMarcelo Dias Sanchespt_BR
dc.date.accessioned2023-07-14T20:45:54Z-
dc.date.available2023-07-14T20:45:54Z-
dc.date.issued2016-02-01-
dc.citation.volume35pt_BR
dc.citation.issue2016pt_BR
dc.citation.spage29pt_BR
dc.citation.epage33pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.trim.2016.01.006pt_BR
dc.identifier.issn09663274pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56309-
dc.description.resumoBackground: Several risk factors influence survival after liver transplantation (LT). Some research has demonstrated a relationship between soluble tumor necrosis factor receptors (sTNFRs) and worse clinical liver disease outcomes, but there are no data showing an association between sTNFRs and outcomes after LT. The primary aim of this study was to determine whether an association exists between perioperative sTNFRs and renal dysfunction or mortality after LT. Methods: Data were collected prospectively from 122 patients submitted to deceased-donor orthotopic LT. Blood samples were collected at seven different perioperative times and analyzed by ELISA. The statistical analysis included univariate analysis followed by logistic regression. The predictive value of significant variables was assessed using ROC curves. Results: One-month and 1-year LT survivals were 91% and 81%, respectively. Increased levels of soluble tumor necrosis factor receptor 1 (sTNF-R1) after 24 h of graft perfusion were associated with postoperative Renal Replacement Therapy (RRT) (OR 1.25) and 1-year mortality (OR 1.1). RRT was associated with 30-day and 1-year LT mortality, with OR 19.78 and 45.45, respectively. Conclusion: A higher sTNF-R1 level measured 24 h after graft perfusion is an independent predictor of RRT and 1-year mortality after LT.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CIRURGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofTransplant Immunology-
dc.rightsAcesso Restritopt_BR
dc.subjectCytokinespt_BR
dc.subjectLiver transplantationpt_BR
dc.subjectMortalitypt_BR
dc.subjectRenal dysfunctionpt_BR
dc.subjectSoluble tumor necrosis factor receptorpt_BR
dc.subject.otherCitocinaspt_BR
dc.subject.otherTransplante de Fígadopt_BR
dc.subject.otherMortalidadept_BR
dc.subject.otherSíndrome de Fanconipt_BR
dc.titleSoluble tumor necrosis factor receptors as predictors of 1-year mortality and renal dysfunction after liver transplantationpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/abs/pii/S0966327416300077?via%3Dihubpt_BR
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