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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56310
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dc.creatorNatalia Pessoarochapt_BR
dc.creatorAntonio Lucio Teixeira Juniorpt_BR
dc.creatorPaula Luciana Scalzopt_BR
dc.creatorIzabela Guimarães Barbosapt_BR
dc.creatorSalvina Maria de Campos-carlipt_BR
dc.creatorLívia Duarte Tavarespt_BR
dc.creatorMariana Soares de Souzapt_BR
dc.creatorPaulo Pereira Christopt_BR
dc.creatorHelton José Reispt_BR
dc.creatorAna Cristina Simões e Silvapt_BR
dc.date.accessioned2023-07-14T20:52:46Z-
dc.date.available2023-07-14T20:52:46Z-
dc.date.issued2016-07-14-
dc.citation.volume368pt_BR
dc.citation.spage235pt_BR
dc.citation.epage239pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jns.2016.07.031pt_BR
dc.identifier.issn0022510Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56310-
dc.description.resumoBackground: The pathogenesis of PD remains elusive. The renin-angiotensin-system (RAS) has recently been implicated in the degeneration of dopaminergic neurons. This study aimed to compare plasma levels of components of the RAS of individuals with PD with controls. We also investigated the association between these circulating markers and motor, depressive and cognitive parameters. Methods: Thirty PD patients and twenty controls were subjected to clinical evaluation, including cognitive and depressive symptoms assessment. Plasma levels of Angiotensin (Ang) I, Ang II, Ang- (1–7), angiotensin converting enzyme (ACE) and ACE2 were measured by Enzyme-Linked Immunosorbent Assay (ELISA). Results: PD patients presented lower plasma levels of Ang I, Ang II and Ang- (1–7) than control individuals. Among PD patients, lower circulating levels of angiotensins were associated with increased severity of depressive symptoms. Conclusions: This is the first study showing that peripheral levels of RAS components are changed in PD and as sociated with depressive symptoms.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of the Neurological Sciences-
dc.rightsAcesso Restritopt_BR
dc.subjectParkinson's diseasept_BR
dc.subjectRenin-angiotensin systempt_BR
dc.subjectNon-motor symptomspt_BR
dc.subjectDepressionpt_BR
dc.subjectCognitionpt_BR
dc.subject.otherDoença de Parkinsonpt_BR
dc.subject.otherSistema Renina-Angiotensinapt_BR
dc.subject.otherDepressãopt_BR
dc.subject.otherCogniçãopt_BR
dc.titlePeripheral levels of angiotensins are associated with depressive symptoms in parkinson's diseasept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.jns-journal.com/article/S0022-510X(16)30446-4/fulltextpt_BR
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