Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/56322| Type: | Artigo de Periódico |
| Title: | Mechanisms underlying chemotherapy-associated mucositis: the role of inflammatory mediators and potential therapeutic targets |
| Authors: | Zelia Menezes Garcia Raquel Duque do Nascimento Arifa Caio Tavares Fagundes Danielle da Glória de Souza |
| Abstract: | Chemotherapy-induced mucositis is a common, often severe, side effect experienced by cancer patients during their treatment, which is a major challenge for successful anticancer therapy. As chemotherapy regimens evolve to include more efficacious agents, mucositis is increasingly becoming a major cause of dose-limiting toxicity and merits further investigation. This condition is characterised by both inflammation and loss of cells from the epithelial barrier of the gastrointestinal tract. This article reviews the current understanding of the inflammatory mechanisms behind chemotherapy’s toxic effect on the gastrointestinal tract and provides evidence that inflammation is a key factor behind gastrointestinal toxicity of chemotherapy. The authors discuss potential therapeutic targets that can contribute to mucositis treatment and prevention. |
| Subject: | Quimioterapia Sistema gastrointestinal - Doenças |
| language: | por |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE MICROBIOLOGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.33590/emjgastroenterol/10310983. |
| URI: | http://hdl.handle.net/1843/56322 |
| Issue Date: | 2018 |
| metadata.dc.url.externa: | https://www.emjreviews.com/gastroenterology/article/editors-pick-mechanisms-underlying-chemotherapy-associated-mucositis-the-role-of-inflammatory-mediators-and-potential-therapeutic-targets/ |
| metadata.dc.relation.ispartof: | European Medical Journal Gastroenterology |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Mechanisms Underlying Chemotherapy-Associated Mucositis The Role of Inflammatory Mediators and Potential Therapeutic Targets.pdf | 1.02 MB | Adobe PDF | View/Open |
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