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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56333
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dc.creatorIsabella Luisa da Silva Gurgelpt_BR
dc.creatorFrederico Marianetti Sorianipt_BR
dc.creatorKarina Talita de Oliveira Santana Jorgept_BR
dc.creatorNathália Luisa Sousa de Oliveira Malaccopt_BR
dc.creatorJéssica Amanda Marques Souzapt_BR
dc.creatorMarina Campos Rochapt_BR
dc.creatorMarina Faria Fernandespt_BR
dc.creatorFlávia Rayssa Braga Martinspt_BR
dc.creatorIran Malavazipt_BR
dc.creatorMauro Martins Teixeirapt_BR
dc.date.accessioned2023-07-14T22:48:01Z-
dc.date.available2023-07-14T22:48:01Z-
dc.date.issued2019-
dc.citation.volume4pt_BR
dc.citation.issue3pt_BR
dc.citation.spage1pt_BR
dc.citation.epage15pt_BR
dc.identifier.doihttps://doi.org/10.1128/msphere.00350-19pt_BR
dc.identifier.issn2379-5042pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56333-
dc.description.resumoAspergillus fumigatus is a filamentous fungus which causes invasive pulmonary aspergillosis in immunocompromised individuals. In fungi, cell signaling and cell wall plasticity are crucial for maintaining physiologic processes. In this context, Msb2 is an important signaling mucin responsible for activation of a variety of mitogen-activated protein kinase (MAPK)-dependent signaling pathways that regulate cell growth in several organisms, such as the cell wall integrity (CWI) pathway. Here, we aimed to characterize the MSB2 homologue in A. fumigatus. Our results showed that MsbA plays a role in the vegetative and reproductive development of the fungus, in stress adaptation, and in resistance to antifungal drugs by modulating the CWI pathway gene expression. Importantly, cell wall composition is also responsible for activation of diverse receptors of the host immune system, thus leading to a proper immune response. In a model of acute Aspergillus pulmonary infection, results demonstrate that the ΔmsbA mutant strain induced less inflammation with diminished cell influx into the lungs and lower cytokine production, culminating in increased lethality rate. These results characterize for the first time the role of the signaling mucin MsbA in the pathogen A. fumigatus, as a core sensor for cell wall morphogenesis and an important regulator of virulence.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAmerican Society for Microbiologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAspergillus fumigatuspt_BR
dc.subjectCell wall integritypt_BR
dc.subjectImmune responsept_BR
dc.subjectMSB2pt_BR
dc.subjectMucinpt_BR
dc.subjectVirulencept_BR
dc.subject.otherBiologiapt_BR
dc.subject.otherAspergillus fumigatuspt_BR
dc.subject.otherParedes celular fúngicapt_BR
dc.titleThe aspergillus fumigatus mucin msba regulates the cell wall integrity pathway and controls recognition of the fungus by the immune systempt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.asm.org/doi/10.1128/mSphere.00350-19pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1797-6080pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4720-6746pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5823-2184pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4988-7629pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4526-4961pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6944-3008pt_BR
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